Mehta Sudhir Ken, Super Dennis M, Connuck David, Kirchner H Lester, Salvator Ann, Singer Lynn, Fradley Linda Goetz, Thomas James D, Sun Jing Ping
Fairview Hospital and MetroHealth Medical Center, Cleveland, Ohio 44111, USA.
J Am Soc Echocardiogr. 2002 Nov;15(11):1361-6. doi: 10.1067/mje.2002.125288.
During the first 48 hours of life, newborn infants exposed to cocaine in utero have left ventricular diastolic segmental abnormalities. It is unknown whether these abnormalities are transient because of short-term effects or persist in older infants, possibly reflecting a teratogenic effect of cocaine.
This study prospectively evaluated global and segmental systolic and diastolic cardiac parameters by color kinesis. The patients were 2- to 6-month-old infants who were exposed to cocaine in utero (N = 56). Their data were compared with normal control patients with no intrauterine drug exposure (N = 60) and newborns exposed to drugs other than cocaine (N = 72).
At the age of 2 to 6 months, there was no significant difference in the measured color kinesis parameters among the cocaine-exposed and the 2 control groups (infants prenatally exposed to other drugs and no drugs). Infants exposed to heavy cocaine prenatally, as compared with the noncocaine-exposed group, had a significant (P =.007) increase in septal fractional area change during left ventricular filling.
At 2 to 6 months of age, infants have recovered from initial left ventricular diastolic segmental alterations seen in the first 48 hours of life except for the septal wall in the heavily cocaine-exposed group.
在出生后的头48小时内，子宫内接触可卡因的新生儿存在左心室舒张期节段性异常。这些异常是由于短期效应而短暂存在，还是在较大婴儿中持续存在，可能反映可卡因的致畸作用，目前尚不清楚。
本研究通过彩色室壁运动分析前瞻性评估整体和节段性心脏收缩和舒张参数。研究对象为2至6个月大的子宫内接触可卡因的婴儿（N = 56）。将他们的数据与未接触宫内药物的正常对照婴儿（N = 60）以及接触除可卡因外其他药物的新生儿（N = 72）进行比较。
在2至6个月大时，接触可卡因的婴儿与两个对照组（产前接触其他药物和未接触药物的婴儿）之间，所测量的彩色室壁运动参数没有显著差异。与未接触可卡因的组相比，产前大量接触可卡因的婴儿在左心室充盈期间的室间隔分数面积变化显著增加（P =.007）。
在2至6个月大时，除了大量接触可卡因组的室间隔壁外，婴儿已从出生后头48小时内出现的最初左心室舒张期节段性改变中恢复。
