磷脂酶C-γ1的调控机制。
The mechanism of phospholipase C-gamma1 regulation.
作者信息
Kim M J, Kim E, Ryu S H, Suh P G
机构信息
Department of Life Science, Pohang University of Science and Technology, Kyungbuk, Korea.
出版信息
Exp Mol Med. 2000 Sep 30;32(3):101-9. doi: 10.1038/emm.2000.18.
Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-gamma1.
磷脂酶C（PLC）1水解磷脂酰肌醇4,5-二磷酸以生成第二信使，即肌醇1,4,5-三磷酸（IP3）和二酰基甘油（DAG）。IP3诱导细胞内游离Ca2+短暂增加，而DAG直接激活蛋白激酶C。在用生长因子刺激细胞时，PLC-γ1在与受体酪氨酸激酶和非受体酪氨酸激酶结合并被其磷酸化后被激活。在本综述中，我们将聚焦于PLC-γ1的激活机制和调节功能。
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