Bou R, Domínguez A, Fontanals D, Sanfeliu I, Pons I, Renau J, Pineda V, Lobera E, Latorre C, Majó M, Salleras L
Department of Health and Social Security, Hospital Universitari Sant Joan de Déu, Spain.
Eur J Epidemiol. 2000 Jun;16(6):521-6. doi: 10.1023/a:1007632122570.
The objective of this study was to determine the prevalence of healthy Haemophilus influenzae (Hi) pharyngeal carriers in a representative sample of the Catalonian school population, as well as the factors associated. A two-stage cluster sampling was carried out. Parents were given a questionnaire to collect information on sociodemographic and epidemiological variables. A pharyngeal swab was performed on children when informed consent was given by parents, and was cultured on chocolate agar with 260 microg/ml bacitracin. Of the 1212 children studied, 316 (26%) H. influenzae carriers were detected: 5 (0.4%) serotype b, 1 (0.08%) serotype c, 6 (0.5%) serotype e, 5 (0.4%) serotype f, and 299 (24.7%) non-typable. Age, gender and geographical location were the only variables associated with H. influenzae carrier status. The prevalence of non-typable H. influenzae carriers was similar to that of studies carried out in other countries, while that of serotype b carriers was similar to the remainder of H. influenzae capsulates, and lower than that described in previous studies. These data are in accordance with the low incidence of the disease observed in our context, although the possibility that the vaccine coverage may have affected the results of this study cannot be dismissed.
本研究的目的是确定加泰罗尼亚学校人群代表性样本中健康流感嗜血杆菌（Hi）咽部携带者的患病率及其相关因素。采用两阶段整群抽样法。向家长发放问卷以收集社会人口统计学和流行病学变量信息。在获得家长知情同意后，对儿童进行咽拭子采样，并接种于含260微克/毫升杆菌肽的巧克力琼脂上培养。在1212名研究儿童中，检测到316名（26%）流感嗜血杆菌携带者：5名（0.4%）为b型血清型，1名（0.08%）为c型血清型，6名（0.5%）为e型血清型，5名（0.4%）为f型血清型，299名（24.7%）为不可分型。年龄、性别和地理位置是与流感嗜血杆菌携带状态相关的仅有的变量。不可分型流感嗜血杆菌携带者的患病率与其他国家开展的研究相似，而b型血清型携带者的患病率与其他有荚膜的流感嗜血杆菌相似，且低于先前研究中所描述的患病率。尽管不能排除疫苗接种覆盖率可能影响本研究结果的可能性，但这些数据与我们观察到的该疾病的低发病率相符。
