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本文引用的文献

1
Hippocampal stem cells differentiate into excitatory and inhibitory neurons.
Eur J Neurosci. 2000 Feb;12(2):677-88. doi: 10.1046/j.1460-9568.2000.00953.x.
2
Postsynaptic target specificity of neurotrophin-induced presynaptic potentiation.神经营养因子诱导的突触前增强的突触后靶点特异性。
Neuron. 2000 Jan;25(1):151-63. doi: 10.1016/s0896-6273(00)80879-x.
3
Vasoactive intestinal peptide. Link between electrical activity and glia-mediated neurotrophism.血管活性肠肽。电活动与胶质细胞介导的神经营养作用之间的联系。
Ann N Y Acad Sci. 1999;897:17-26. doi: 10.1111/j.1749-6632.1999.tb07875.x.
4
Synaptic assembly of the brain in the absence of neurotransmitter secretion.在缺乏神经递质分泌的情况下大脑的突触组装。
Science. 2000 Feb 4;287(5454):864-9. doi: 10.1126/science.287.5454.864.
5
Locomotor activity causes a rapid up-regulation of vasoactive intestinal peptide in the rat hippocampus.运动活动会导致大鼠海马体中血管活性肠肽的快速上调。
Hippocampus. 1999;9(5):534-41. doi: 10.1002/(SICI)1098-1063(1999)9:5<534::AID-HIPO7>3.0.CO;2-R.
6
Running enhances neurogenesis, learning, and long-term potentiation in mice.跑步可增强小鼠的神经发生、学习能力和长期增强效应。
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13427-31. doi: 10.1073/pnas.96.23.13427.
7
Neurotrophin-evoked rapid excitation through TrkB receptors.神经营养因子通过TrkB受体引发快速兴奋。
Nature. 1999 Oct 28;401(6756):918-21. doi: 10.1038/44847.
8
VIP and D-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death.血管活性肠肽（VIP）和D-丙氨酸肽T-酰胺释放趋化因子，可预防HIV-1糖蛋白120诱导的神经元死亡。
Brain Res. 1999 Aug 14;838(1-2):27-36. doi: 10.1016/s0006-8993(99)01644-3.
9
Three-dimensional relationships between hippocampal synapses and astrocytes.海马体突触与星形胶质细胞之间的三维关系。
J Neurosci. 1999 Aug 15;19(16):6897-906. doi: 10.1523/JNEUROSCI.19-16-06897.1999.
10
Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses.谷氨酸受体锚定蛋白与兴奋性突触的分子组织
Ann N Y Acad Sci. 1999 Apr 30;868:483-93. doi: 10.1111/j.1749-6632.1999.tb11317.x.

一种调节神经元分化的胶质细胞衍生信号。

A glia-derived signal regulating neuronal differentiation.

作者信息

Blondel O, Collin C, McCarran W J, Zhu S, Zamostiano R, Gozes I, Brenneman D E, McKay R D

机构信息

Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

J Neurosci. 2000 Nov 1;20(21):8012-20. doi: 10.1523/JNEUROSCI.20-21-08012.2000.

DOI:10.1523/JNEUROSCI.20-21-08012.2000
PMID:11050122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6772724/
Abstract

Astrocytes are present in large numbers in the nervous system, are associated with synapses, and propagate ionic signals. Astrocytes influence neuronal physiology by responding to and releasing neurotransmitters, but the mechanisms that establish the close interaction between these cells are not defined. Here we use hippocampal neurons in culture to demonstrate that vasoactive intestinal polypeptide (VIP) promotes neuronal differentiation through activity-dependent neurotrophic factor (ADNF), a protein secreted by VIP-stimulated astroglia. ADNF is produced by glial cells and acts directly on neurons to promote glutamate responses and morphological development. ADNF causes secretion of neurotrophin 3 (NT-3), and both proteins regulate NMDA receptor subunit 2A (NR2A) and NR2B. These data suggest that the VIP-ADNF-NT-3 neuronal-glial pathway regulates glutamate responses from an early stage in the synaptic development of excitatory neurons and may also contribute to the known effects of VIP on learning and behavior in the adult nervous system.

摘要

星形胶质细胞大量存在于神经系统中，与突触相关联，并能传递离子信号。星形胶质细胞通过对神经递质作出反应并释放神经递质来影响神经元生理功能，但尚未明确建立这些细胞间紧密相互作用的机制。在此，我们利用培养的海马神经元来证明，血管活性肠肽（VIP）通过活性依赖神经营养因子（ADNF）促进神经元分化，ADNF是一种由VIP刺激的星形胶质细胞分泌的蛋白质。ADNF由神经胶质细胞产生，并直接作用于神经元以促进谷氨酸反应和形态发育。ADNF会导致神经营养因子3（NT-3）的分泌，且这两种蛋白质都能调节N-甲基-D-天冬氨酸受体亚基2A（NR2A）和NR2B。这些数据表明，VIP-ADNF-NT-3神经元-神经胶质细胞通路从兴奋性神经元突触发育的早期阶段就开始调节谷氨酸反应，并且可能也有助于VIP对成年神经系统学习和行为的已知影响。