Stephens Len, Ellson Chris, Hawkins Phillip
The Babraham Institute, Babraham, Cambridge CB2 4AT, UK.
Curr Opin Cell Biol. 2002 Apr;14(2):203-13. doi: 10.1016/s0955-0674(02)00311-3.
Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, phagocytosis and phagosome maturation in leukocytes.
通过选择性破坏磷酸肌醇3激酶（PI3K）的活性，并使用绿色荧光蛋白标记的能够在体内特异性结合PI3K脂质产物的结构域衍生物，已表明该信号酶家族在白细胞的趋化性、吞噬作用和吞噬体成熟中具有至关重要且独特的作用。
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