Soda H, Oka M, Soda M, Nakatomi K, Kawabata S, Suenaga M, Kasai T, Yamada Y, Kamihira S, Kohno S
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
Jpn J Cancer Res. 2000 Oct;91(10):960-5. doi: 10.1111/j.1349-7006.2000.tb00871.x.
Smoking prevalence remains high (around 60%) among Japanese males, but smoking initiation among males born in the 1930s decreased by approximately 10% due to economic difficulties following World War II. The present study was designed to examine whether this temporary decline in smoking initiation influenced the subsequent incidence of lung cancers, especially adenocarcinoma. Trends of lung cancer incidence by histological type in both sexes were investigated using data from the population-based cancer registry in Nagasaki, Japan, from 1986 through 1995. During this period, 5668 males and 2309 females were diagnosed as having lung cancer, and the overall incidence of lung cancers among both sexes remained stable. However, males aged 55 - 59 years showed a decrease in the age-specific incidence of adenocarcinoma and squamous-cell carcinoma (P < 0.05 and P < 0.01, respectively). In birth cohort analyses, the incidence of adenocarcinoma and squamous-cell carcinoma was lower in the 1935 - 1939 birth male cohort than in the successive cohorts. The incidence of lung cancers among females with low smoking prevalence did not change with birth cohort. The low smoking initiation among the 1935 - 1939 birth male cohort appeared to have resulted in a decreased incidence of adenocarcinoma and squamous cell carcinoma among middle-aged Japanese males. The present study suggests that smoking prevention has an effect in reducing the incidence of lung adenocarcinoma, as well as squamous-cell carcinoma, among smokers.
日本男性的吸烟率仍然很高（约60%），但由于二战后经济困难，20世纪30年代出生的男性吸烟率下降了约10%。本研究旨在探讨吸烟率的这种暂时下降是否影响了随后肺癌的发病率，尤其是腺癌。利用日本长崎基于人群的癌症登记处1986年至1995年的数据，调查了两性按组织学类型划分的肺癌发病率趋势。在此期间，5668名男性和2309名女性被诊断患有肺癌，两性肺癌的总体发病率保持稳定。然而，55 - 59岁的男性腺癌和鳞状细胞癌的年龄别发病率有所下降（分别为P < 0.05和P < 0.01）。在出生队列分析中，1935 - 1939年出生的男性队列中腺癌和鳞状细胞癌的发病率低于随后的队列。吸烟率低的女性肺癌发病率并未随出生队列而变化。1935 - 1939年出生的男性队列中吸烟率低似乎导致了日本中年男性腺癌和鳞状细胞癌发病率的下降。本研究表明，预防吸烟对降低吸烟者中肺腺癌以及鳞状细胞癌的发病率有效果。
