Jürgens U
German Primate Center, Göttingen, Germany.
J Acoust Soc Am. 2000 Oct;108(4):1393-6. doi: 10.1121/1.1289204.
To find out whether there exist additional regions in the pontine brainstem, apart from the phonatory motoneuron pools involved in vocal motor control, the effects of a localized blockade of excitatory neurotransmission in the pons were studied on squirrel monkey vocalization. Vocalization was elicited by electrical stimulation of the periaqueductal gray of the midbrain. Blockade was carried out by stereotaxic injections of kynurenic acid, a nonspecific glutamate antagonist. It was found that injections made into the ventrolateral pons around the ventral nucleus of the lateral lemniscus and superior olive could block periaqueductally elicited vocalization. Injections were only effective ipsilaterally, not contralaterally to the stimulation site. The blockade was limited to one particular class of calls, all of which had in common a characteristic stereotyped frequency modulation over several kHz. It is concluded that critical processing steps of vocal motor control take place in the periolivary region.
为了弄清楚除了参与发声运动控制的发声运动神经元池之外，脑桥脑干中是否还存在其他区域，研究了脑桥局部兴奋性神经传递阻断对松鼠猴发声的影响。发声由中脑导水管周围灰质的电刺激诱发。通过立体定位注射犬尿氨酸（一种非特异性谷氨酸拮抗剂）来进行阻断。结果发现，在外侧丘系腹侧核和上橄榄核周围的脑桥腹外侧进行注射可阻断导水管周围诱发的发声。注射仅在同侧有效，对刺激部位的对侧无效。这种阻断仅限于一类特定的叫声，所有这些叫声的共同特征是在几千赫兹范围内有特征性的刻板频率调制。得出的结论是，发声运动控制的关键处理步骤发生在橄榄周区域。
