Basso A, Guitelman A, Amezua L, Molocznik I, Mancini A, Montez M
Neurochirurgie. 1975 Mar-Apr;21(2):111-20.
Among the 230 pituitary adenomas that we treated, 23 patients aging from 20 to 39 had a prolactin-secretary pituitary adenoma and were all demonstrating an amenorrhea-galactorrhea syndrom. It is not always very fast to establish the more and more frequently observed etiology of this clinical state, especially when the existence, or not, of a pituitary adenoma is concerned. A total endocrinological study (determination of serum prolactin and inhibition and stimulation tests) of all hypothalamic-hypophyseal-peripheric axis must be done, as well as precise radiological studies, able of showing small distortions of the sella turcica. On our patients, the diagnosis of a pituitary tumor and the surgical intervention have never been decided on the base of only one element of the diagnosis. We now think that only the presence, at the same time, of clinical, radiological and biological signs, however small they are, allows the decision for a surgical intervention when prolactin-secreting pituitary adenoma is suspected.
在我们治疗的230例垂体腺瘤患者中，23例年龄在20至39岁之间，患有分泌催乳素的垂体腺瘤，均表现为闭经-溢乳综合征。要确定这种临床状态越来越常见的病因并不总是很快，尤其是在涉及垂体腺瘤是否存在的情况下。必须对整个下丘脑-垂体-外周轴进行全面的内分泌学研究（测定血清催乳素以及抑制和刺激试验），以及能够显示蝶鞍微小变形的精确放射学研究。对于我们的患者，垂体肿瘤的诊断和手术干预从未仅基于诊断的一个要素来决定。我们现在认为，只有同时出现临床、放射学和生物学体征，无论多么轻微，当怀疑为分泌催乳素的垂体腺瘤时，才允许决定进行手术干预。
