Rodríguez-Artalejo F, Guallar-Castillón P, Banegas Banegas J R, Gutiérrez-Fisac J L, del Rey Calero J
Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain.
Eur Heart J. 2000 Nov;21(22):1841-52. doi: 10.1053/euhj.2000.2320.
Coronary risk factors raise the risk of other chronic disorders. We therefore tested the hypothesis that the geographic distribution of ischaemic heart disease mortality is associated with that of other chronic diseases with which it shares risk factors.
For the 50 provinces of Spain, we collected mortality data for the period 1980-1995 from the national vital statistics. We calculated age-adjusted mortality rates for the leading causes of death in quintiles of provincial distribution of ischaemic heart disease mortality, and correlation coefficients with respect to provincial ischaemic heart disease mortality. As expected, because they share risk factors with ischaemic heart disease, mortality from cerebrovascular disease, malignant tumours, lung cancer, respiratory diseases, chronic obstructive pulmonary disease, diseases of the digestive system, cirrhosis of the liver and all causes, increase with the rise from lower to higher quintiles of ischaemic heart disease mortality. Ischaemic heart disease mortality registered correlations over 0.5 (P<0.001) with mortality from many of the above diseases in the periods 1980-1984 and 1991-1995. Expectations were similarly borne out for disorders not sharing risk factors with ischaemic heart disease, in that mortality from prostate and breast cancer, injury and poisoning, traffic accidents and ill-defined causes in most cases did not show a provincial association with ischaemic heart disease mortality. In general, these results were observed for both sexes and across all age groups.
Ischaemic heart disease mortality is associated with mortality from chronic diseases which share coronary risk factors, across provinces of Spain over the period 1980-1995. This suggests that the geographic variation in such chronic diseases is due to common factors, potentially susceptible to similar preventive interventions.
冠心病危险因素会增加患其他慢性疾病的风险。因此，我们检验了以下假设：缺血性心脏病死亡率的地理分布与其他具有共同危险因素的慢性疾病的地理分布相关。
对于西班牙的50个省份，我们从国家人口动态统计数据中收集了1980 - 1995年期间的死亡率数据。我们计算了缺血性心脏病死亡率分布五等分区间内主要死因的年龄调整死亡率，以及与各省份缺血性心脏病死亡率的相关系数。正如预期的那样，由于脑血管疾病、恶性肿瘤、肺癌、呼吸系统疾病、慢性阻塞性肺疾病、消化系统疾病、肝硬化以及所有死因与缺血性心脏病有共同的危险因素，其死亡率随着缺血性心脏病死亡率从低到高的五等分区间上升而增加。在1980 - 1984年和1991 - 1995年期间，缺血性心脏病死亡率与上述多种疾病的死亡率之间的相关性超过0.5（P<0.001）。对于与缺血性心脏病没有共同危险因素的疾病，情况同样如此，因为前列腺癌、乳腺癌、损伤与中毒、交通事故以及死因不明的死亡率在大多数情况下与各省份的缺血性心脏病死亡率没有关联。总体而言，这些结果在男女两性以及所有年龄组中均有观察到。
在1980 - 1995年期间，西班牙各省份的缺血性心脏病死亡率与具有共同冠心病危险因素的慢性疾病死亡率相关。这表明这些慢性疾病的地理差异是由共同因素导致的，可能易于采取类似的预防性干预措施。
