Koffler D
Pathobiol Annu. 1975;5:221-47.
SLE is a syndrome with protean clinical manifestation, a diversity of immunologic abnormalities, and a host of potential etiologic agents. In recent years, considerable information has been accumulated concerning the immunopathogenesis of SLE, and significant advances have been made in the treatment of the disease by utilizing immunosuppressive therapy. Further investigation will be needed to clarify the mechanisms of tissue injury, especially as they relate to the CNS, and to identify the factors responsible for initiating the SLE syndrome.
系统性红斑狼疮（SLE）是一种临床表现多样、免疫异常多样且有多种潜在病因的综合征。近年来，关于SLE的免疫发病机制已积累了大量信息，并且通过使用免疫抑制疗法在该疾病的治疗方面取得了显著进展。需要进一步研究以阐明组织损伤的机制，尤其是与中枢神经系统相关的机制，并确定引发SLE综合征的因素。
