Boyer R S, Sun N C, Verity A, Nies K M, Louie J S
J Rheumatol. 1980 Sep-Oct;7(5):645-50.
Immune deposits in the choroid of patients with systemic lupus erythematosus (SLE) are thought to relate to the pathogenesis of central nervous system (CNS) SLE. Using an immunoperoxidase technique, we found the presence of immunoglobulin heavy and light chains in the choroid stroma and/or in the ependymal cells in all of 7 patients with SLE, 2 of 4 with rheumatoid arthritis, but not in 3 subjects without autoimmune disease. The occurrence, pattern or intensity of the immunoglobulin deposits did not distinguish the patients with or without clinical neuropsychiatric manifestations. Thus, the presence of immune deposits in the choroid plexus is not specific for CNS involvement in SLE.
系统性红斑狼疮（SLE）患者脉络丛中的免疫沉积物被认为与中枢神经系统（CNS）SLE的发病机制有关。我们采用免疫过氧化物酶技术，在7例SLE患者的脉络丛基质和/或室管膜细胞中均发现了免疫球蛋白重链和轻链，4例类风湿关节炎患者中有2例发现，而3例无自身免疫性疾病的受试者中未发现。免疫球蛋白沉积物的出现、模式或强度并不能区分有无临床神经精神表现的患者。因此，脉络丛中存在免疫沉积物并非SLE中枢神经系统受累的特异性表现。
