唾液腺良性与恶性嗜酸性细胞瘤的Ki-67免疫组化评估

Benign and malignant oncocytoma of the salivary glands with an immunohistochemical evaluation of Ki-67.

作者信息

Ito K, Tsukuda M, Kawabe R, Nakagawa C, Matsushita K, Kubota A, Furukawa M, Kameda Y, Ito T

机构信息

Department of Otorhinolaryngology, School of Medicine, Yokohama City University, Yokohama, Japan.

出版信息

ORL J Otorhinolaryngol Relat Spec. 2000 Nov-Dec;62(6):338-41. doi: 10.1159/000027766.

DOI:10.1159/000027766

PMID:11054019

Abstract

We present two cases of benign oncocytoma derived from the parotid gland and minor salivary gland and one case of malignant oncocytoma from the parotid gland. The proliferative activity of the tumor cells was evaluated immunohistochemically for Ki-67. The average frequency of Ki-67-positive cells was 3.3% in the benign oncocytomas and 6.5% in the malignant oncocytoma. The higher frequency of Ki-67-positive cells in the malignant oncocytoma might reflect active cell proliferation. Ki-67 immunostaining may be useful in distinguishing a benign oncocytoma from a malignant oncocytoma.

摘要

我们报告了两例源自腮腺和小唾液腺的良性嗜酸性细胞瘤以及一例源自腮腺的恶性嗜酸性细胞瘤。通过免疫组织化学方法对肿瘤细胞的增殖活性进行Ki-67评估。良性嗜酸性细胞瘤中Ki-67阳性细胞的平均频率为3.3%，恶性嗜酸性细胞瘤中为6.5%。恶性嗜酸性细胞瘤中Ki-67阳性细胞的较高频率可能反映了活跃的细胞增殖。Ki-67免疫染色可能有助于区分良性嗜酸性细胞瘤和恶性嗜酸性细胞瘤。