细胞毒性和免疫抑制药物对免疫系统的影响。
Effects of cytotoxic and immunosuppressive agents on the immune system.
作者信息
Bodey G P, Hersh E M, Valdivieso M, Feid R, Rodriguez V
出版信息
Postgrad Med. 1975 Dec;58(7):67-74. doi: 10.1080/00325481.1975.11714222.
Most chemotherapeutic agents are myelosuppressive and immunosuppressive. Consequently their use greatly increases a patient's susceptibility to infection. Neutropenia creates greater risk than lymphopenia and is a particular problem in patients with acute leukemia who are treated with combination chemotherapy. Chemotherapy is less immunosuppressive if given in short intensive courses rather than continuously. Continuous therapy causes severe depression of antibody production and inhibition of delayed hypersensitivity reaction.
大多数化疗药物都有骨髓抑制和免疫抑制作用。因此，使用这些药物会大大增加患者感染的易感性。中性粒细胞减少比淋巴细胞减少带来的风险更大，对于接受联合化疗的急性白血病患者来说，这是一个特别的问题。如果采用短期强化疗程给药，化疗的免疫抑制作用会减弱，而持续给药则会导致抗体产生严重受抑以及迟发型超敏反应受到抑制。
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