Marinaccio M, Putignano G, Geusa S, Quaranta M, Schönauer L M, Latiano T, Stanziano A, Alfonso R, Del Bianco A
I Department of Obstetrics and Gynecology, University Medical School of Bari, Italy.
Eur J Gynaecol Oncol. 2000;21(4):423-5.
Raised levels of steroid hormones may be detected in women with ovarian cancer at the time of diagnosis. The goal of this study was to investigate the levels of progesterone, testosterone and estradiol-17beta in patients with relapsed epithelial ovarian cancer. We studied 52 patients with a histologic diagnosis of ovarian cancer; 46 of 52 patients were affected by epithelial tumors, two patients had sexcord-stromal tumors, one patient had a germ cell tumor and three patients had a metastatic cancer from the bowel. Of 34 patients with disease relapse, none had elevated serum testosterone levels (>1 ng/ml), one patient (2.9%) had an elevated serum progesterone level (>1.24 ng/ml) and two patients (5.9%) had elevated estradiol-17beta levels (>28 pg/ml). The relationship between the three hormone levels at the time of initial treatment and at relapse was tested using the Students's t-test. At the time of initial treatment venous concentrations of progesterone, estradiol-17beta and testosterone were higher and statistically different (p<0.05) from samples obtained at the time of relapse in the same patients. No significant differences were found between patients studied at the time of relapse and the control group. Measurement of progesterone, estradiol-17beta and testosterone is not helpful in detecting disease relapse in patients with epithelial ovarian cancer.
在卵巢癌女性患者确诊时可能检测到甾体激素水平升高。本研究的目的是调查复发性上皮性卵巢癌患者的孕酮、睾酮和雌二醇-17β水平。我们研究了52例经组织学诊断为卵巢癌的患者；52例患者中有46例患有上皮性肿瘤，2例患有性索间质肿瘤，1例患有生殖细胞肿瘤，3例患有来自肠道的转移性癌。在34例疾病复发的患者中，没有患者血清睾酮水平升高（>1 ng/ml），1例患者（2.9%）血清孕酮水平升高（>1.24 ng/ml），2例患者（5.9%）雌二醇-17β水平升高（>28 pg/ml）。使用学生t检验来检测初始治疗时和复发时这三种激素水平之间的关系。在初始治疗时，同一患者复发时采集的样本中，孕酮、雌二醇-17β和睾酮的静脉浓度更高，且具有统计学差异（p<0.05）。在复发时研究的患者与对照组之间未发现显著差异。测量孕酮、雌二醇-17β和睾酮对检测上皮性卵巢癌患者的疾病复发没有帮助。
