Henry M H, Wyatt R D, Fletchert O J
Department of Poultry Science, University of Georgia, Athens 30602, USA.
Poult Sci. 2000 Oct;79(10):1378-84. doi: 10.1093/ps/79.10.1378.
An investigation of the toxicity of fumonisin B1 (FB1), a toxic metabolite of Fusarium moniliforme, in broiler chicks was conducted. Purified FB1 (98.1% pure) was incorporated into the diets of broiler chicks at 0, 20, 40, and 80 mg/kg, and fed to chicks from 0 to 21 d of age. Dietary FB1, at concentrations of 80 mg/kg or less, did not adversely affect body weight, feed efficiency, or water consumption of broiler chicks. The relative weights of the liver, spleen, kidney, proventriculus, and bursa of Fabricius were also unaffected (P < 0.05) by any dietary concentration of FB1 compared with the control (0 mg/kg) group. Total liver lipids of chicks fed 40 or 80 mg FB1/kg were significantly lower than those of the chicks fed either 0 or 20 mg FB1/kg of feed. Liver sphinganine concentration and the sphinganine:sphingosine ratio were increased significantly in all treated groups. Chicks fed dietary FB1 at 80 mg/kg had significantly higher serum glutamate oxaloacetate aminotransaminase:aspartate aminotransferase ratios and levels of free sphinganine in the serum. The results of this investigation agree with the results previously described, in which FB1 was supplied to diets from the use of F. moniliforme-contaminated grain; therefore, the use of such material as the source of the mycotoxin in animal feeding studies is appropriate.
对串珠镰刀菌的有毒代谢产物伏马菌素B1（FB1）在肉鸡中的毒性进行了研究。将纯化的FB1（纯度98.1%）以0、20、40和80毫克/千克的剂量添加到肉鸡日粮中，并在0至21日龄期间饲喂给雏鸡。日粮中浓度为80毫克/千克及以下的FB1对肉鸡的体重、饲料效率或饮水量没有不利影响。与对照组（0毫克/千克）相比，任何日粮浓度的FB1对肝脏、脾脏、肾脏、腺胃和法氏囊的相对重量也没有影响（P<0.05）。饲喂40或80毫克FB1/千克的雏鸡肝脏总脂质显著低于饲喂0或20毫克FB1/千克饲料的雏鸡。所有处理组的肝脏鞘氨醇浓度和鞘氨醇：鞘脂比均显著增加。饲喂80毫克/千克日粮FB1的雏鸡血清谷氨酸草酰乙酸转氨酶：天冬氨酸转氨酶比值和血清中游离鞘氨醇水平显著更高。本研究结果与先前描述的结果一致，先前的研究中FB1是通过使用受串珠镰刀菌污染的谷物添加到日粮中的；因此，在动物饲养研究中使用此类材料作为霉菌毒素的来源是合适的。
