Knutsen Helle-Katrine, Alexander Jan, Barregård Lars, Bignami Margherita, Brüschweiler Beat, Ceccatelli Sandra, Cottrill Bruce, Dinovi Michael, Edler Lutz, Grasl-Kraupp Bettina, Hogstrand Christer, Hoogenboom Laurentius Ron, Nebbia Carlo Stefano, Petersen Annette, Rose Martin, Roudot Alain-Claude, Schwerdtle Tanja, Vleminckx Christiane, Vollmer Günter, Wallace Heather, Dall'Asta Chiara, Eriksen Gunnar-Sundstøl, Taranu Ionelia, Altieri Andrea, Roldán-Torres Ruth, Oswald Isabelle P
EFSA J. 2018 May 25;16(5):e05242. doi: 10.2903/j.efsa.2018.5242. eCollection 2018 May.
Fumonisins, mycotoxins primarily produced by and , occur predominantly in cereal grains, especially in maize. The European Commission asked EFSA for a scientific opinion on the risk to animal health related to fumonisins and their modified and hidden forms in feed. Fumonisin B (FB ), FB and FB are the most common forms of fumonisins in feedstuffs and thus were included in the assessment. FB , FB and FB have the same mode of action and were considered as having similar toxicological profile and potencies. For fumonisins, the EFSA Panel on Contaminants in the Food Chain (CONTAM) identified no-observed-adverse-effect levels (NOAELs) for cattle, pig, poultry (chicken, ducks and turkeys), horse, and lowest-observed-adverse-effect levels (LOAELs) for fish (extrapolated from carp) and rabbits. No reference points could be identified for sheep, goats, dogs, cats and mink. The dietary exposure was estimated on 18,140 feed samples on FB representing most of the feed commodities with potential presence of fumonisins. Samples were collected between 2003 and 2016 from 19 different European countries, but most of them from four Member States. To take into account the possible occurrence of hidden forms, an additional factor of 1.6, derived from the literature, was applied to the occurrence data. Modified forms of fumonisins, for which no data were identified concerning both the occurrence and the toxicity, were not included in the assessment. Based on mean exposure estimates, the risk of adverse health effects of feeds containing FB was considered very low for ruminants, low for poultry, horse, rabbits, fish and of potential concern for pigs. The same conclusions apply to the sum of FB and their hidden forms, except for pigs for which the risk of adverse health effect was considered of concern.
伏马菌素是主要由 和 产生的霉菌毒素,主要存在于谷物中,尤其是玉米。欧盟委员会要求欧洲食品安全局就伏马菌素及其在饲料中的修饰形式和隐蔽形式对动物健康的风险提供科学意见。伏马菌素B1(FB1)、FB2和FB3是饲料中最常见的伏马菌素形式,因此被纳入评估。FB1、FB2和FB3具有相同的作用模式,被认为具有相似的毒理学特征和效力。对于伏马菌素,欧洲食品安全局食物链污染物小组(CONTAM)确定了牛、猪、家禽(鸡、鸭和火鸡)、马的无观察到不良影响水平(NOAELs),以及鱼(从鲤鱼外推)和兔子的最低观察到不良影响水平(LOAELs)。未确定绵羊、山羊、狗、猫和水貂的参考点。根据18140份代表大多数可能存在伏马菌素的饲料商品的FB1饲料样本估计了膳食暴露量。样本于2003年至2016年期间从19个不同的欧洲国家收集,但大多数来自四个成员国。为了考虑隐蔽形式的可能存在,将从文献中得出的1.6的附加因子应用于发生数据。未确定关于伏马菌素修饰形式的发生和毒性数据,因此未将其纳入评估。基于平均暴露估计,含有FB1的饲料对反刍动物产生不良健康影响的风险被认为非常低,对家禽、马、兔子、鱼来说风险较低,对猪来说存在潜在担忧。对于FB1及其隐蔽形式的总和,同样的结论适用,但猪的不良健康影响风险被认为令人担忧。