氦氧混合气体不能改善机械通气的毛细支气管炎患儿的气体交换。
Helium-oxygen mixture does not improve gas exchange in mechanically ventilated children with bronchiolitis.
作者信息
Gross M F, Spear R M, Peterson B M
机构信息
Children's Hospital Health Center, San Diego, California, USA.
出版信息
Crit Care. 2000;4(3):188-92. doi: 10.1186/cc692. Epub 2000 Apr 13.
STATEMENT OF FINDINGS
Varying concentrations of helium-oxygen (heliox) mixtures were evaluated in mechanically ventilated children with bronchiolitis. We hypothesized that, with an increase in the helium:oxygen ratio, and therefore a decrease in gas density, ventilation and oxygenation would improve in children with bronchiolitis. Ten patients, aged 1-9 months, were mechanically ventilated in synchronized intermittent mandatory ventilation (SIMV) mode with the following gas mixtures delivered at 15-min intervals: 50%/50% nitrogen/oxygen, 50%/50% heliox, 60%/40% heliox, 70%/30% heliox, and return to 50%/50% nitrogen/oxygen. The use of different heliox mixtures compared with 50%/50% nitrogen/oxygen in mechanically ventilated children with bronchiolitis did not result in a significant or noticeable decrease in ventilation or oxygenation.
研究结果声明
对机械通气的小儿支气管炎患儿使用不同浓度的氦氧混合气体（氦氧混合气）进行了评估。我们假设，随着氦氧比例的增加，进而气体密度降低，小儿支气管炎患儿的通气和氧合情况会得到改善。10名年龄在1至9个月的患儿以同步间歇指令通气（SIMV）模式进行机械通气，每隔15分钟输送以下混合气体：50%/50%氮/氧、50%/50%氦氧混合气、60%/40%氦氧混合气、70%/30%氦氧混合气，然后恢复至50%/50%氮/氧。在机械通气的小儿支气管炎患儿中，与50%/50%氮/氧相比，使用不同的氦氧混合气体并未导致通气或氧合情况出现显著或明显的下降。
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