Cervenákov I, Kopecný M, Jancár M, Chovan D, Mal'a M
Department of Urology and Andrology, University Hospital Bratislava, Slovak Republic.
Int Urol Nephrol. 2000;32(1):77-9. doi: 10.1023/a:1007164319067.
From 1995 to 1997 the authors have assessed 31 patients with histologically verified advanced carcinoma of the prostate (CaP) and the ensuing symptom of 'hot flush'. Patients underwent transurethral resection of the prostate (TURP), bilateral orchiectomy (OE) and combined androgen blockade (CAB) by the administration of non-steroid antiadrogens. The authors present the mechanism of the genesis of the 'hot flush' symptom as well as its subjective manifestations, methods of laboratory monitoring as well as their experience with the treatment of this symptom. 50 mg tablets cyproterone acetate administered twice daily or Androcur depot 300 mg i.m. inj. once in 14 days were the main factors in the treatment of 'hot flushes' which reduced subjective difficulties in 80.6% of the patients studied.
1995年至1997年期间，作者评估了31例经组织学证实为晚期前列腺癌（CaP）且伴有“潮热”症状的患者。患者接受了经尿道前列腺切除术（TURP）、双侧睾丸切除术（OE）以及通过给予非甾体类抗雄激素药物进行联合雄激素阻断（CAB）。作者阐述了“潮热”症状的发生机制、主观表现、实验室监测方法以及他们对该症状的治疗经验。每天两次服用50毫克醋酸环丙孕酮片或每14天肌肉注射一次300毫克安雄长效注射剂，是治疗“潮热”的主要因素，这些措施使80.6%的研究患者主观不适症状减轻。
