Smith J A
Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2765.
J Urol. 1994 Jul;152(1):132-4. doi: 10.1016/s0022-5347(17)32835-5.
In a prospective, comparative study 68 men were treated for hot flushes after androgen deprivation therapy for prostate cancer. Complete responses (elimination of hot flushes) were rare in patients receiving either combined phenobarbital plus ergotamine or clonidine. Of the men receiving either diethylstilbestrol or megestrol acetate 70% had a complete response, while another 20% had a greater than 50% decrease in the severity of hot flushes. Based upon a lower incidence of side effects, oral megestrol acetate was the preferred treatment for hot flushes in this study.
在一项前瞻性对照研究中，68名因前列腺癌接受雄激素剥夺治疗后出现潮热的男性接受了治疗。接受苯巴比妥加麦角胺或可乐定联合治疗的患者很少有完全缓解（潮热消失）的情况。接受己烯雌酚或醋酸甲地孕酮治疗的男性中，70%有完全缓解，另有20%潮热严重程度降低超过50%。基于较低的副作用发生率，醋酸甲地孕酮口服制剂是本研究中治疗潮热的首选药物。
