Uchiyama M, Okawa M, Shibui K, Kim K, Tagaya H, Kudo Y, Kamei Y, Hayakawa T, Urata J, Takahashi K
Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 1-7-3 Kohnodai, 272-0827, Ichikawa, Japan.
Neurosci Lett. 2000 Nov 17;294(2):101-4. doi: 10.1016/s0304-3940(00)01551-2.
Changes in the phase relation between sleep timing and the circadian pacemaker are suspected to have an etiological significance in circadian rhythm sleep disorders. Simultaneous recordings of rest-activity and rectal temperature in seven sighted delayed sleep phase syndrome (DSPS) patients, seven sighted non-24-h sleep-wake syndrome (non-24) patients, and 14 healthy controls were made for 10-14 days continuously in the subjects' homes. We found that sleep length and the interval from the body temperature (BT) trough to sleep offset were significantly longer in both non-24 and DSPS patients than in the controls, and that the interval between sleep onset and the BT trough was significantly less in the non-24 patients than in the DSPS patients and the controls. We postulate these alterations in phase relation to be associated with phase changes of the circadian pacemaker via different illumination timings.
睡眠时间与昼夜节律起搏器之间相位关系的变化被怀疑在昼夜节律睡眠障碍中具有病因学意义。对7名视力正常的延迟睡眠相位综合征（DSPS）患者、7名视力正常的非24小时睡眠-觉醒综合征（非24）患者和14名健康对照者，在其家中连续10 - 14天同时记录休息-活动情况和直肠温度。我们发现，非24和DSPS患者的睡眠时间以及从体温（BT）谷值到睡眠结束的间隔均显著长于对照组，且非24患者睡眠开始至BT谷值的间隔显著短于DSPS患者和对照组。我们推测这些相位关系的改变通过不同的光照时间与昼夜节律起搏器的相位变化相关。
