Ozaki S, Uchiyama M, Shirakawa S, Okawa M
Department of Psychophysiology, National Institute of Mental Health, National Center for Neurology and Psychiatry, Ichikawa, Japan.
Sleep. 1996 Jan;19(1):36-40.
In order to clarify the relationship between sleep-wake and core body temperature rhythms in the delayed sleep phase syndrome (DSPS), we conducted simultaneous monitoring of these rhythms in seven patients with DSPS and nine healthy control subjects for 6-10 days during their conventional sleep-wake schedules. The sleep onset and offset times were determined visually from sleep logs, and the temperature data were fitted to 24-hour cosinor curves by the least squares method. The sleep onset and offset times and temperature nadir were delayed significantly in patients with DSPS compared with the control subjects (p = 0.01, 0.003 and 0.02, respectively). We also found that sleep length and the temperature nadir to sleep offset interval were significantly longer in the DSPS than the control group (p = 0.03 and 0.02, respectively). The latter finding suggests that the inability of the patients with DSPS to normally phase-advance their circadian rhythm may be a consequence of masking of the advance portion of their phase-response curve by the last hours of their prolonged sleep episodes.
为了阐明睡眠相位延迟综合征（DSPS）中睡眠-觉醒与核心体温节律之间的关系，我们在7例DSPS患者和9名健康对照者按照其常规睡眠-觉醒时间表进行了6至10天的这些节律的同步监测。睡眠开始和结束时间通过睡眠日志直观确定，温度数据通过最小二乘法拟合为24小时余弦曲线。与对照组相比，DSPS患者的睡眠开始和结束时间以及体温最低点明显延迟（分别为p = 0.01、0.003和0.02）。我们还发现，DSPS患者的睡眠时间和体温最低点至睡眠结束间隔比对照组明显更长（分别为p = 0.03和0.02）。后一发现表明，DSPS患者无法正常提前其昼夜节律可能是由于其延长睡眠期的最后几个小时掩盖了其相位反应曲线的提前部分所致。
