Shibata K, Moriyama M, Fukushima T, Kaetsu A, Miyazaki M, Une H
Department of Public Health, School of Medicine, Fukuoka University, Japan.
J Epidemiol. 2000 Sep;10(5):310-6. doi: 10.2188/jea.10.310.
Chronic atrophic gastritis (CAG) is well known as a precancerous lesion of the stomach, and Helicobacter pylori (H. pylori) infection increases the risk of CAG. While recent studies have reported that green tea consumption decreases the risk of gastric cancer, there has been no study analyzing the relationship between green tea consumption and the both risks H. pylori infection and CAG. We conducted a cross-sectional study on 636 subjects living in a farming village in Japan to examine the relationship among green tea consumption, H. pylori infection, and CAG. Smoking, alcohol drinking, consumption of four beverages, including green tea, and of five foods were investigated as lifestyle factors that may affect H. pylori infection and CAG. The measurement of H. pylori-IgG antibodies was used to define H. pylori infection, and serum pepsinogens were used to define of CAG. The unconditional logistic regression model was used for analyzing each odds ratio (OR). H. pylori infection was positively associated with the risk of CAG (OR = 3.73; 95% confidence interval [CI], 2.59-5.36). High green tea consumption (more than 10 cups per day) was negatively associated with the risk of CAG, even after adjustment for H. pylori infection and lifestyle factors associated with green tea consumption (OR = 0.63; 95% CI, 0.43-0.93). These results support the hypothesis that high green tea consumption prevents CAG.
慢性萎缩性胃炎（CAG）是众所周知的胃癌前病变，幽门螺杆菌（H. pylori）感染会增加患CAG的风险。虽然最近的研究报告称饮用绿茶可降低患胃癌的风险，但尚无研究分析饮用绿茶与H. pylori感染和CAG这两种风险之间的关系。我们对居住在日本一个村庄的636名受试者进行了一项横断面研究，以探讨饮用绿茶、H. pylori感染和CAG之间的关系。作为可能影响H. pylori感染和CAG的生活方式因素，我们调查了吸烟、饮酒、包括绿茶在内的四种饮料以及五种食物的摄入量。通过检测H. pylori-IgG抗体来确定H. pylori感染情况，并用血清胃蛋白酶原检测来确定CAG情况。采用无条件逻辑回归模型分析各比值比（OR）。H. pylori感染与CAG风险呈正相关（OR = 3.73；95%置信区间[CI]，2.59 - 5.36）。即使在对H. pylori感染和与饮用绿茶相关的生活方式因素进行调整后，大量饮用绿茶（每天超过10杯）与CAG风险呈负相关（OR = 0.63；95% CI，0.43 - 0.93）。这些结果支持大量饮用绿茶可预防CAG这一假说。
