Fukao A, Komatsu S, Tsubono Y, Hisamichi S, Ohori H, Kizawa T, Ohsato N, Fujino N, Endo N, Iha M
Department of Public Health, Tohoku University School of Medicine, Japan.
Cancer Causes Control. 1993 Jul;4(4):307-12. doi: 10.1007/BF00051332.
To evaluate an association between Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis (CAG), an established precursor of gastric cancer, we performed a cross-sectional study using IgG antibody against H. pylori and pepsinogens of blood donors in four prefectures in Japan. Although a geographic correlation between the age-adjusted prevalence rates for H. pylori infection and those for CAG was not seen, the age-adjusted odds ratios (OR) of H. pylori infection for CAG were high in each area (around five for men and from four to 12.6 for women). The association between them weakened with advancing age; the ORs in the youngest age group (16-29 yrs) and in the oldest age group (50-64 yrs) were 12.5 and 2.8 for men, and 11.5 and 5.2 for women, respectively. These findings suggest that H. pylori infection is strongly associated with CAG, while there are some other factors interacting in the development of CAG. A prospective cohort study in which CAG and H. pylori infection are taken into account will be necessary to assess the risks of gastric cancer.
为评估幽门螺杆菌（H. pylori）感染与慢性萎缩性胃炎（CAG，一种已明确的胃癌前体）之间的关联，我们在日本四个县对献血者进行了一项横断面研究，检测了针对H. pylori的IgG抗体和胃蛋白酶原。虽然未观察到H. pylori感染的年龄调整患病率与CAG的年龄调整患病率之间存在地理相关性，但各地区H. pylori感染导致CAG的年龄调整优势比（OR）均较高（男性约为5，女性为4至12.6）。它们之间的关联随年龄增长而减弱；最年轻年龄组（16 - 29岁）和最年长年龄组（50 - 64岁）中，男性的OR分别为12.5和2.8，女性的OR分别为11.5和5.2。这些发现表明，H. pylori感染与CAG密切相关，而在CAG的发生发展中还有其他一些因素相互作用。有必要进行一项前瞻性队列研究，纳入CAG和H. pylori感染情况，以评估胃癌风险。
