肺炎衣原体是否存在于多发性硬化症患者的脑损伤中？
Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?
作者信息
Hammerschlag M R, Ke Z, Lu F, Roblin P, Boman J, Kalman B
机构信息
Chlamydia Research Laboratory, Department of Pediatrics, Division of Infectious Diseases, SUNY Health Science Center at Brooklyn, Brooklyn, New York, USA.
出版信息
J Clin Microbiol. 2000 Nov;38(11):4274-6. doi: 10.1128/JCM.38.11.4274-4276.2000.
Abstract
We investigated the presence of Chlamydia pneumoniae in 81 normal and pathological specimens obtained from postmortem brain tissues of patients with multiple sclerosis and with other neurological or nonneurological diseases. The assays used included PCR amplification of all DNA samples in the initial study. Culture and a second PCR amplification of the organism in a subset of 19 brain specimens were also performed in two separate laboratories. All results were negative. Thus, this study on a large number of brain tissues suggests that C. pneumoniae is not involved in inflammatory demyelination.
摘要
我们对从患有多发性硬化症以及其他神经或非神经疾病的患者尸检脑组织中获取的81份正常和病理标本进行了肺炎衣原体检测。在初始研究中，所用检测方法包括对所有DNA样本进行PCR扩增。还在两个独立实验室对19份脑标本的子集进行了该生物体的培养及第二次PCR扩增。所有结果均为阴性。因此，这项针对大量脑组织的研究表明，肺炎衣原体与炎症性脱髓鞘无关。
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