Scherak O, Fritzsche H, Thumb N, Kolarz G, Stingl G, Holubar K
Z Rheumatol. 1975 Sep-Oct;34(9-10):342-9.
The clinical features of 6 patients with symptoms of various connective tissue diseases and rheumatoid arthritis are reported. The frequency of symptoms corresponded to that of the syndrome, which Sharp et al. (1971) termed mixed connective tissue disease. The antibodies to an extractable nuclear antigen are a characteristic feature. Moreover, one may detect a speckled staining pattern by indirect immunofluorescence. In addition, moderate immunoglobulin deposits were observed in the skin and kidneys of our patients. The pathomechanism of these deposits is discussed.
报告了6例有各种结缔组织病和类风湿性关节炎症状患者的临床特征。症状出现频率与夏普等人（1971年）称为混合性结缔组织病的综合征相符。抗可提取核抗原抗体是其特征性表现。此外，通过间接免疫荧光可检测到斑点状染色模式。另外，在我们患者的皮肤和肾脏中观察到中等程度的免疫球蛋白沉积。对这些沉积物的发病机制进行了讨论。
