Liu Y, McKenna E, Figueroa D J, Blevins R, Austin C P, Bennett P B, Swanson R
Department of Bioinformatics, Merck & Co., West Point, PA 19486, USA.
Cytogenet Cell Genet. 2000;90(1-2):60-3. doi: 10.1159/000015662.
A novel human Kir5.1 (inward rectifier K+ channel subunit, gene name KCNJ16) was identified through database searches. This human KCNJ16 was mapped to chromosome 17q25. The full-length cDNA was identified and its genomic structure was determined. Tissue distribution studies showed that human KCNJ16 is significantly expressed in human kidney, pancreas and thyroid gland. In situ hybridization revealed expression in convoluted tubule cells of kidney and in the acinar and ductal cells of pancreas. These suggest that human Kir5.1 may be involved in the regulation of fluid and pH balance, thus making it a potential therapeutic target for hypertension, renal failure, or pancreatic disease.
通过数据库搜索鉴定出一种新型人类Kir5.1（内向整流钾离子通道亚基，基因名称为KCNJ16）。该人类KCNJ16基因定位于17号染色体q25区域。鉴定出了全长cDNA并确定了其基因组结构。组织分布研究表明，人类KCNJ16在人肾、胰腺和甲状腺中显著表达。原位杂交显示在肾曲小管细胞以及胰腺腺泡和导管细胞中有表达。这些表明人类Kir5.1可能参与了液体和pH平衡的调节，因此使其成为高血压、肾衰竭或胰腺疾病的潜在治疗靶点。
