Zazgornik J, Schmidt P, Kopsa H, Fill W, Deutsch E
Acta Hepatogastroenterol (Stuttg). 1975 Oct;22(5):304-9.
Two renal allograft recipients with acquired immunoglobulin deficiency had a disseminated infection with candida albicans. Septic fever, intrahepatic cholestasis and pulmonary mycotic disease were the prominent clinical symptoms. Recurrence of septic fever during the clinical course was associated with increase of intrahepatic cholestasis. On the other hand there was an amelioration of cholestasis when effective antimycotic therapy was instituted. In our patients there was no evidence that intrahepatic cholestasis was drug-related. It was assumed that toxic metabolits of candida albicans were responsible for intrahepatic cholestasis.
两名获得性免疫球蛋白缺乏的肾移植受者发生了白色念珠菌播散性感染。败血症发热、肝内胆汁淤积和肺部真菌病是主要的临床症状。临床过程中败血症发热的复发与肝内胆汁淤积的加重有关。另一方面，开始有效的抗真菌治疗后胆汁淤积有所改善。在我们的患者中，没有证据表明肝内胆汁淤积与药物有关。据推测，白色念珠菌的毒性代谢产物是肝内胆汁淤积的原因。
