O'Sullivan A J, Kennedy M C, Casey J H, Day R O, Corrigan B, Wodak A D
Department of Medicine, St George Hospital, Sydney, NSW.
Med J Aust. 2000 Sep 18;173(6):323-7. doi: 10.5694/j.1326-5377.2000.tb125667.x.
To document adverse effects of anabolic-androgenic steroid (AAS) use in community-based users attending a medical clinic.
Prospective recruitment, questionnaire-based interview, physical examination and investigations, with follow-up, of people who attended, anonymously, an inner-city hospital clinic established specifically to examine AAS use.
58 men, comprising 27 past AAS users, 14 present users and 17 potential users (who formed the control group).
Clinical adverse effects and abnormal laboratory findings.
Cyclical use of oral and intramuscular, human and veterinary AASs were reported. The most commonly reported source of AASs was friends (59%), gymnasiums (25%) and doctors (14%). The most common reported adverse effects were alterations in libido (61%), changes in mood (48%), reduced testis volume (46%) and acne (43%). Although mean systolic and diastolic blood pressure was not significantly different between groups, five present (29%), 10 past (37%) and one potential user (8%) were hypertensive. Gynaecomastia was found in 10 past users (37%; P<0.01 v. potential users), two present users (12%) and no potential users. Mean testis volume was significantly smaller in present users (18 mL; P<0.02) than in the other groups. Twenty past users (83%), eight present users (62%) and five potential users (71%) had abnormal liver function test results (P=0.5). After discussion of test results, only 11 participants (19%) reported they would not use AASs in the future.
Adverse effects were reported by or detected in most of the AAS users who attended the clinic. Despite awareness of adverse consequences, most participants planned future use of AASs.
记录在一家诊所就诊的社区合成代谢雄激素类固醇（AAS）使用者的不良反应。
对匿名前往一家专门检查AAS使用情况的市中心医院诊所就诊的人员进行前瞻性招募、基于问卷的访谈、体格检查及调查，并进行随访。
58名男性，包括27名既往AAS使用者、14名当前使用者和17名潜在使用者（组成对照组）。
临床不良反应及实验室检查异常结果。
报告了口服、肌肉注射、人用及兽用AAS的周期性使用情况。最常报告的AAS来源是朋友（59%）、健身房（25%）和医生（14%）。最常报告的不良反应是性欲改变（61%）、情绪变化（48%）、睾丸体积减小（46%）和痤疮（43%）。尽管各组间平均收缩压和舒张压无显著差异，但有5名当前使用者（29%）、10名既往使用者（37%）和1名潜在使用者（8%）患有高血压。10名既往使用者（37%；与潜在使用者相比P<0.01）、2名当前使用者（12%）出现乳腺增生，潜在使用者中未出现。当前使用者的平均睾丸体积（18 mL；P<0.02）显著小于其他组。20名既往使用者（83%）、8名当前使用者（62%）和5名潜在使用者（71%）肝功能检查结果异常（P=0.5）。在讨论检查结果后，只有11名参与者（19%）表示他们未来不会使用AAS。
在该诊所就诊的大多数AAS使用者报告了不良反应或被检测出有不良反应。尽管知晓不良反应，但大多数参与者仍计划未来使用AAS。
