Bedi Harjot, Hammond Carl, Sanders David, Yang Hui-Min, Yoshida Eric M
Department of Medicine Internal Medicine Residency Training Program, The University of British Columbia, Vancouver, British Columbia, Canada.
Division of Gastroenterology, The University of British Columbia, Vancouver, British Columbia, Canada.
ACG Case Rep J. 2021 Jan 7;8(1):e00518. doi: 10.14309/crj.0000000000000518. eCollection 2021 Jan.
Anabolic steroids are well-known to cause liver injury, which may manifest with jaundice and elevated liver enzymes. Selective androgen receptor modulators (SARMs) have been developed to enhance muscle bulk without the side effects associated with exogenous androgen steroids. We report a case of significant cholestatic liver injury associated with a SARM, ostarine (enobosarm), similar to that associated with anabolic steroids. Liver injury from SARMs has not been reported frequently, and we speculate that this may be seen more often as the consumption of SARMs increases in the athletic market.
众所周知，合成代谢类固醇会导致肝损伤，其表现可能为黄疸和肝酶升高。选择性雄激素受体调节剂（SARMs）已被研发出来，以增加肌肉量，同时避免外源性雄激素类固醇带来的副作用。我们报告了一例与SARM奥施力（恩博萨胺）相关的严重胆汁淤积性肝损伤病例，该损伤与合成代谢类固醇所致的肝损伤相似。SARM引起的肝损伤此前报道较少，我们推测随着SARM在体育市场的消费量增加，这种情况可能会更常见。
