Werkö L
Am Heart J. 1976 Jan;91(1):87-98. doi: 10.1016/s0002-8703(76)80439-5.
The importance of the many well-published epidemiologic studies for the philosophy of prevention of ischemic heart disease has led to this analysis of the background design and early results of three such studies, i.e., the Framingham study, the National Pooling Project, and the Stockholm Prospective Study. Besides indicating certain flaws in the early design, it is demonstrated that the authors usually press their factual data to conclusions that are not only really valid, with some exceptions. This analysis leads to the conclusion that high blood pressure and cigarette smoking seem to be much more important for the development of ischemic heart disease than high serum lipids in the populations studied. They are, furthermore, selected in such a way that the results cannot have any bearing on the general population and, in particular, on its lower and higher social strata.
众多已发表的关于缺血性心脏病预防理念的流行病学研究的重要性，促使对三项此类研究（即弗雷明汉姆研究、国家汇总项目和斯德哥尔摩前瞻性研究）的背景设计及早期结果进行了此番分析。除了指出早期设计中的某些缺陷外，还表明作者们通常会将实际数据强行得出一些结论，而这些结论并非真正有效，只有一些例外情况。该分析得出的结论是，在所研究的人群中，高血压和吸烟对于缺血性心脏病的发展似乎比高血清脂质更为重要。此外，研究对象的选取方式使得研究结果与一般人群，尤其是社会底层和高层人群并无关联。
