Litaker D, Kippes C M, Gallagher T E, O'Connor M E
Cuyahoga County Board of Health, Rainbow Babies and Childrens Hospital, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Pediatrics. 2000 Nov;106(5):E69. doi: 10.1542/peds.106.5.e69.
Annual blood lead (BPb) screening is recommended for children </=2 years of age residing in high-risk areas. Strategies for identifying these areas exist but lack specificity. We sought to develop an efficient method for identifying risk factors for undue lead exposure in children by using community variables.
Logistic regression for model development in one half of the sample followed by validation of the model in the remaining half.
The association between selected census tract characteristics from 19 Ohio counties and the BPb test results of children living in those census tracts was evaluated. The dependent variable, high-risk status, was defined as a census tract with >/=12% of BPb test results >/=10 microg/dL.
Data from 897 census tracts were available. Higher risk for lead toxicity existed in areas where: 1) >/=55% of houses were built before 1950 (adjusted odds ratio [AOR]: 10.9 [6.1,19.6]); 2) >/=35% of residents were black (AOR: 3.5 [2.0,6. 3]); 3) >/=35% of residents had less than a high school education (AOR: 6.1 [3.6,10.4]); and 4) >/=50% of housing units were renter-occupied (AOR: 3.6 [2.1,6.2]). Receiver operator characteristic (ROC) curves demonstrated no significant differences after applying the model in a second dataset.
Several community characteristics predict risk for lead toxicity in children and may provide a useful approach to focus lead screening, especially in communities where public health resources are limited. The approach described here may also prove helpful in identifying factors within a community associated with other environmental public health hazards for children.
建议对居住在高危地区的2岁及以下儿童进行年度血铅(BPb)筛查。识别这些地区的策略是存在的,但缺乏特异性。我们试图通过使用社区变量来开发一种有效的方法,以识别儿童铅暴露过量的风险因素。
在一半样本中进行模型开发的逻辑回归,然后在另一半样本中对模型进行验证。
评估了俄亥俄州19个县选定的普查区特征与居住在这些普查区的儿童的BPb检测结果之间的关联。因变量高危状态被定义为BPb检测结果≥10微克/分升的比例≥12%的普查区。
可获得来自897个普查区的数据。在以下地区存在更高的铅中毒风险:1)≥55%的房屋建于1950年之前(调整优势比[AOR]:10.9[6.1,19.6]);2)≥35%的居民为黑人(AOR:3.5[2.0,6.3]);3)≥35%的居民未接受过高中教育(AOR:6.1[3.6,10.4]);4)≥50%的住房单元为租户占用(AOR:3.6[2.1,6.2])。在第二个数据集中应用该模型后,受试者操作特征(ROC)曲线显示无显著差异。
几个社区特征可预测儿童铅中毒风险,并可能为集中铅筛查提供有用的方法,尤其是在公共卫生资源有限的社区。这里描述的方法也可能有助于识别社区内与儿童其他环境公共卫生危害相关的因素。