Peeker R, Haghsheno M A, Holmäng S, Fall M
Department of Urology, Sahlgrenska University Hospital Göteborg, Sweden.
J Urol. 2000 Dec;164(6):1912-5; discussion 1915-6. doi: 10.1016/s0022-5347(05)66916-9.
We conducted a prospective, double-blind study with a crossover design of intravesical bacillus Calmette-Guerin (BCG) and dimethyl sulfoxide to determine whether patients with classic and nonulcer interstitial cystitis, respectively, might benefit from either regimen.
A total of 21 patients, including 11 with classic and 10 with nonulcer interstitial cystitis, randomly underwent treatments with intravesical BCG or dimethyl sulfoxide and, if not improved, were treated with the other substance after a washout period. All 21 patients were evaluated with symptom questionnaires, including a visual analog pain scale and voiding diaries.
Regardless of regimen, there was no improvement in maximal functional capacity. There was a reduction in urinary frequency following dimethyl sulfoxide treatment but only in the classic subtype (p <0.05), whereas no reduction was seen following BCG in either subtype. A substantial pain decrease was noted in classic (p <0.05) as well as nonulcer (p <0.05) interstitial cystitis following dimethyl sulfoxide.
Intravesical BCG has been presented as a promising new option for treatment of interstitial cystitis. We failed to demonstrate benefit from this treatment. Dimethyl sulfoxide had no positive effect on maximal functional capacity but resulted in a significant reduction in pain and urinary frequency, although only in patients with classic interstitial cystitis.
我们进行了一项前瞻性、双盲、采用卡介苗（BCG）膀胱内灌注与二甲亚砜交叉设计的研究，以确定经典型和非溃疡型间质性膀胱炎患者是否分别能从这两种治疗方案中获益。
总共21例患者，其中11例为经典型间质性膀胱炎，10例为非溃疡型间质性膀胱炎，随机接受膀胱内灌注BCG或二甲亚砜治疗，若病情未改善，在洗脱期后换用另一种药物治疗。所有21例患者均通过症状问卷进行评估，包括视觉模拟疼痛量表和排尿日记。
无论采用何种治疗方案，最大功能容量均无改善。二甲亚砜治疗后尿频有所减少，但仅在经典型亚型中出现（p<0.05），而卡介苗治疗后两种亚型均未出现尿频减少。二甲亚砜治疗后，经典型（p<0.05）和非溃疡型（p<0.05）间质性膀胱炎的疼痛均大幅减轻。
膀胱内灌注卡介苗已被视为治疗间质性膀胱炎的一种有前景的新选择。我们未能证明这种治疗有获益。二甲亚砜对最大功能容量无积极影响，但可显著减轻疼痛和尿频，不过仅在经典型间质性膀胱炎患者中有效。
