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类风湿性关节炎滑膜组织产生急性期血清淀粉样蛋白A

Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue.

作者信息

O'Hara R, Murphy E P, Whitehead A S, FitzGerald O, Bresnihan B

机构信息

St Vincent's University Hospital, Dublin, Ireland.

出版信息

Arthritis Res. 2000;2(2):142-4. doi: 10.1186/ar78. Epub 2000 Feb 24.

DOI:10.1186/ar78
PMID:11062604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC17807/
Abstract

Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA expression was confirmed in all samples obtained from patients with RA, but not in normal synovium. A-SAA mRNA expression was also demonstrated in cultured RA synoviocytes. A-SAA protein was identified in the supernatants of primary synoviocyte cultures, and its expression colocalized with sites of macrophage accumulation and with some vascular endothelial cells. It is concluded that A-SAA is produced by inflamed RA synovial tissue. The known association between the acute-phase response and progressive joint damage may be the direct result of synovial A-SAA-induced effects on cartilage degradation.

摘要

急性期血清淀粉样蛋白A（A-SAA）是急性期反应的主要成分。类风湿关节炎（RA）中持续的急性期反应与关节损伤增加有关。在所有从RA患者获得的样本中均证实有A-SAA mRNA表达，但在正常滑膜中未检测到。在培养的RA滑膜细胞中也证实有A-SAA mRNA表达。在原代滑膜细胞培养上清液中鉴定出A-SAA蛋白，其表达与巨噬细胞聚集部位以及一些血管内皮细胞共定位。得出的结论是，A-SAA由炎症性RA滑膜组织产生。急性期反应与进行性关节损伤之间已知的关联可能是滑膜A-SAA诱导软骨降解作用的直接结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/3a158c36c9aa/ar-2-2-142-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/ab8d48edc082/ar-2-2-142-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/dd4b75de6725/ar-2-2-142-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/02403abec399/ar-2-2-142-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/b07ecd54dd35/ar-2-2-142-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/3a158c36c9aa/ar-2-2-142-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/ab8d48edc082/ar-2-2-142-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/046a7fb5404e/ar-2-2-142-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/01eccc1ed9f6/ar-2-2-142-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/dd4b75de6725/ar-2-2-142-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/02403abec399/ar-2-2-142-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/b07ecd54dd35/ar-2-2-142-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85d2/17807/3a158c36c9aa/ar-2-2-142-7.jpg

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2
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J Rheumatol. 2000 Jan;27(1):58-63.
3
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Front Immunol. 2024 Apr 12;15:1373745. doi: 10.3389/fimmu.2024.1373745. eCollection 2024.
4
Biomarkers of Cardiovascular Risk in Patients With Rheumatoid Arthritis: Results From the TARGET Trial.类风湿关节炎患者心血管风险的生物标志物：来自 TARGET 试验的结果。
J Am Heart Assoc. 2024 Mar 5;13(5):e032095. doi: 10.1161/JAHA.123.032095. Epub 2024 Feb 28.
5
The Human GP130 Cytokine Receptor and Its Expression-an Atlas and Functional Taxonomy of Genetic Variants.人类 GP130 细胞因子受体及其表达——遗传变异的图谱和功能分类学。
J Clin Immunol. 2023 Dec 22;44(1):30. doi: 10.1007/s10875-023-01603-7.
6
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4
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7
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8
Regulation of extrahepatic apolipoprotein serum amyloid A (ApoSAA) gene expression by interleukin-1 alpha alone: synthesis and secretion of ApoSAA by cultured aortic smooth muscle cells.单独由白细胞介素-1α调控肝外载脂蛋白血清淀粉样蛋白A（ApoSAA）基因表达：培养的主动脉平滑肌细胞合成及分泌ApoSAA
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