Hsieh Y Y, Tsai H D, Chang F C
Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan.
J Assist Reprod Genet. 2000 Sep;17(8):405-8. doi: 10.1023/a:1009458215962.
The purpose was to compare the outcomes between day-5 blastocyst and day-2 embryo transfers.
Infertile women who accepted the ovarian hyperstimulation and oocyte retrieval were divided: Group 1, day 2 embryo transfer, group 2, cultured to day 5 in serum-free sequential culture medium and transfer. Early embryo quality and growth, blastocyst formation and quality, implantation rate (IR) and pregnancy rates (PR) were detected.
Total blastocyst formation rate was 49.4%. Better early embryo quality (days 2, 3) and higher day 3 blastomere number possess higher blastocyst formation rate. The IR for day 2 and day 5 embryos were 10.8% and 22.2%, respectively. The PR in both groups were comparable (37.3% vs. 41.8%).
Blastocyst transfer has higher IR and comparable PR as those of day 2 embryo transfer. Early embryo qualities and day 3 blastomere number are useful in predicting the final blastocyst formation. Blastocyst formation rate is not related to maternal age, infertile causes, insemination methods, and early embryo number.
比较第5天囊胚移植与第2天胚胎移植的结局。
将接受卵巢超刺激和卵母细胞采集的不孕女性进行分组：第1组为第2天胚胎移植，第2组在无血清序贯培养基中培养至第5天进行移植。检测早期胚胎质量和生长情况、囊胚形成及质量、着床率（IR）和妊娠率（PR）。
囊胚总形成率为49.4%。早期胚胎质量更好（第2、3天）且第3天的卵裂球数量更多，囊胚形成率更高。第2天和第5天胚胎的着床率分别为10.8%和22.2%。两组的妊娠率相当（37.3%对41.8%）。
囊胚移植的着床率高于第2天胚胎移植，妊娠率相当。早期胚胎质量和第3天的卵裂球数量有助于预测最终的囊胚形成。囊胚形成率与产妇年龄、不孕原因、授精方式及早期胚胎数量无关。
