Wong A, Tan K H, Tee C S, Yeo G S
Department of Maternal-Fetal Medicine, KK Women's and Children's Hospital, Singapore.
Singapore Med J. 2000 Apr;41(4):151-5.
The aim of our study was to determine the seroprevalence of cytomegalovirus (CMV), toxoplasma and parvovirus infection in our local antenatal population, and to see the effects, if any, of age, race, parity and nationality on its seroprevalence.
The sera of 120 consecutive antenatal women seen in KK Women's and Children's Hospital between the period of October 1997 and March 1998 were screened for cytomegalovirus (CMV) IgG, toxoplasma IgG and parvovirus B19 IgG and IgM. An antibody titer greater than 1:32 was regarded as positive.
A total of 87.0% of patients were tested seropositive for CMV IgG, 17.2% seropositive for toxoplasma IgG and 30.0% seropositive for parvovirus IgG. There seemed to be a trend of increasing seropositivity with age in all three groups, however only parovirus B19 reached statistical significance. The incidence of all three infections were higher among the Malays, Indians and other races compared to the Chinese.
CMV is endemic in our population and hence the most common infection. Toxoplasmosis and parvovirus is relatively low in our population but this implies that a large proportion of our antenatal women are still susceptible to these infections. Prevention of congenital CMV, toxoplasmosis and parvovirus infection is mainly by educating the antenatal population.
我们研究的目的是确定本地产前人群中巨细胞病毒（CMV）、弓形虫和细小病毒感染的血清流行率，并观察年龄、种族、胎次和国籍对其血清流行率的影响（如有）。
对1997年10月至1998年3月期间在KK妇女儿童医院就诊的120名连续产前妇女的血清进行巨细胞病毒（CMV）IgG、弓形虫IgG和细小病毒B19 IgG及IgM筛查。抗体滴度大于1:32被视为阳性。
总共87.0%的患者CMV IgG检测呈血清阳性，17.2%的患者弓形虫IgG检测呈血清阳性，30.0%的患者细小病毒IgG检测呈血清阳性。在所有三组中，血清阳性率似乎都有随年龄增加的趋势，然而只有细小病毒B19达到统计学意义。与华人相比，马来人、印度人和其他种族中这三种感染的发生率更高。
CMV在我们的人群中呈地方性流行，因此是最常见的感染。弓形虫病和细小病毒在我们的人群中相对较少，但这意味着我们很大一部分产前妇女仍易感染这些疾病。预防先天性CMV、弓形虫病和细小病毒感染主要是通过对产前人群进行教育。
