Partana Pamela, Wan Wei Yee, Chow Xin Yu Venessa, Chan Jerry Kok Yen, Tan Lay Kok, Tan Wei Ching, Lee Piea Peng, Lim Gek Hsiang, Yang Liying
Department of Obstetrics and Gynaecology, Singapore General Hospital, Singapore, Singapore.
Department of Microbiology, Singapore General Hospital, Singapore, Singapore.
Trop Med Health. 2024 Oct 3;52(1):67. doi: 10.1186/s41182-024-00634-z.
Cytomegalovirus (CMV) is the most common congenital infection in pregnancy with potential long-term adverse effects on the fetus. There is limited data on CMV seroprevalence in pregnant women in Singapore, with last reported study dating back over two decades. We look at the latest CMV seroprevalence in antenatal population in Singapore.
Between January 2021 and August 2021, 385 pregnant women receiving antenatal care at Singapore General Hospital were randomly selected for CMV IgG test to be performed on their blood samples collected during the first trimester of their pregnancies. Positivity for CMV IgG represents past exposure prior to pregnancy.
Overall CMV seroprevalence was 71.7% (276/385) (95% CI 067, 0.76, p value < 0.001). The trend of CMV IgG positivity increased with age, 68.3% (95% CI 0.60, 0.76, p value < 0.001) in those aged 20-29, 72.5% (95% CI 0.66, 0.78, p value < 0.001) in the 30-39 age group, and 79.0% (95% CI 0.67, 0.76, p value 0.012) in women over 40.
There is a declining trend in CMV seroprevalence among pregnant women in Singapore, which indicates that a substantial portion of this population faces the risk of primary maternal CMV infection during pregnancy. Emerging research suggests that prenatal treatment with valacyclovir effectively reduces the likelihood of vertical transmission. Considering this evidence, it is imperative to reevaluate the recommendations for universal maternal CMV screening during pregnancy.
巨细胞病毒（CMV）是孕期最常见的先天性感染，可能对胎儿产生长期不良影响。新加坡孕妇中CMV血清阳性率的数据有限，上次报告的研究可追溯到二十多年前。我们研究了新加坡产前人群中最新的CMV血清阳性率。
在2021年1月至2021年8月期间，随机选择了385名在新加坡总医院接受产前护理的孕妇，对她们在妊娠早期采集的血液样本进行CMV IgG检测。CMV IgG阳性表示妊娠前曾有过接触。
总体CMV血清阳性率为71.7%（276/385）（95%可信区间0.67，0.76，p值<0.001）。CMV IgG阳性率随年龄增长呈上升趋势，20-29岁人群中为68.3%（95%可信区间0.60，0.76，p值<0.001），30-39岁年龄组中为72.5%（95%可信区间0.66，0.78，p值<0.001），40岁以上女性中为79.0%（95%可信区间0.67，0.76，p值0.012）。
新加坡孕妇中CMV血清阳性率呈下降趋势，这表明该人群中的很大一部分在孕期面临原发性母体CMV感染的风险。新出现的研究表明，用伐昔洛韦进行产前治疗可有效降低垂直传播的可能性。考虑到这一证据，有必要重新评估孕期普遍进行母体CMV筛查的建议。
