Khoo B P, Giam Y C
National Skin Centre, Singapore.
Singapore Med J. 2000 Feb;41(2):66-8.
Pitted nails is a non-specific entity seen in children that is often associated with various underlying skin disorders such as atopic dermatitis, psoriasis, alopecia areata and lichen planus; and those without such associations are labelled as idiopathic pitted nails. Spontaneous resolution is common but may take several years. Treatment options so far have not been encouraging. This pilot study sought to determine the safety and efficacy of intralesional steroid in the treatment of pitted nails in children.
Children with pitted nails below the age of 12, seen between January 1994 and December 1997, were invited to participate in this study. Symmetrically affected fingernails were selected, topical anaesthetic cream applied and a single dose of triamcinolone acetonide was introduced intralesionally to the proximal nailfold while the contralateral nail acted as control. The degree of pitting of nail surface was documented at months 0, 2 and 4.
Four children were enrolled, and their ages ranged from 4 to 9 years. The degree of pitting was reduced to a mean of 15% of the nail surface in the second month, and 42% in the fourth month. The procedure was fairly well tolerated and no adverse effects were noted.
Intralesional steroid is a safe and acceptable method of treating pitted nails in children with a maximum effect seen in 2 months. In order to sustain a continuous therapeutic effect, a bimonthly treatment is suggested.
点状甲是儿童中可见的一种非特异性表现,常与多种潜在的皮肤疾病相关,如特应性皮炎、银屑病、斑秃和扁平苔藓;而无此类关联的则被标记为特发性点状甲。自发缓解很常见,但可能需要数年时间。到目前为止,治疗选择并不令人鼓舞。这项初步研究旨在确定皮损内注射类固醇治疗儿童点状甲的安全性和有效性。
邀请1994年1月至1997年12月期间就诊的12岁以下点状甲患儿参与本研究。选择双侧受累的指甲,涂抹外用麻醉乳膏,并向近端甲襞皮损内注射单剂量曲安奈德,对侧指甲作为对照。在第0、2和4个月记录指甲表面的点状程度。
招募了4名儿童,年龄在4至9岁之间。点状程度在第二个月降至指甲表面平均15%,在第四个月降至42%。该操作耐受性良好,未观察到不良反应。
皮损内注射类固醇是治疗儿童点状甲的一种安全且可接受的方法,最大效果在2个月时可见。为维持持续的治疗效果,建议每两个月治疗一次。