Pelzer Christin, Iorizzo Matilde
Department of Dermatology, Venereology and Allergology, Kantonsspital St. Gallen, 9000 St. Gallen, Switzerland.
Private Dermatology Practice, 6500 Bellinzona, Switzerland.
J Clin Med. 2024 Jun 3;13(11):3292. doi: 10.3390/jcm13113292.
Alopecia areata (AA) is a common form of non-scarring alopecia characterized by acute hair loss. Nail involvement, though not always present, can occur in AA patients. Nail changes are more frequent in severe forms of AA and in children. Literature related to nail changes in AA was comprehensively reviewed after a search on the PubMed database without time restrictions in order to identify common clinical presentations and associated factors to aid clinicians with the correct evaluation and management of these dystrophies. Nail changes in AA include pitting, trachyonychia, leukonychia, red lunula, and miscellaneous alterations such as longitudinal ridging and brittle nails. Nail changes are usually asymptomatic but, nevertheless, sometimes cosmetically disfiguring and can be associated with a reduced quality of life and impaired daily activities. Nail changes in AA may precede or follow hair loss and can occur as an isolated finding. Diagnosis may require a biopsy for definitive identification. Spontaneous improvement is possible, particularly in children, and treatment is not always necessary. Further research is, however, needed to establish a consensus on treatment approaches according to age and severity.
斑秃(AA)是一种常见的非瘢痕性脱发,其特征为急性脱发。AA患者可能会出现甲受累情况,不过并非总是出现。甲改变在重度AA患者及儿童中更为常见。为了确定常见临床表现及相关因素,以便帮助临床医生正确评估和处理这些甲营养不良,我们在PubMed数据库上进行了无时间限制的检索,对与AA甲改变相关的文献进行了全面综述。AA的甲改变包括甲凹点、粗糙甲、白甲、红甲半月征,以及其他改变,如纵嵴和脆甲。甲改变通常无症状,但有时会影响美观,可能导致生活质量下降和日常活动受限。AA的甲改变可能在脱发之前或之后出现,也可能单独出现。诊断可能需要活检以明确。甲改变有可能自发改善,尤其是在儿童中,而且并非总是需要治疗。然而,还需要进一步研究以就根据年龄和严重程度的治疗方法达成共识。