Stanisz G J, Henkelman R M
Departments of Medical Biophysics and Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Magn Reson Med. 2000 Nov;44(5):665-7. doi: 10.1002/1522-2594(200011)44:5<665::aid-mrm1>3.0.co;2-m.
Gd-DTPA T(1) relaxivity of water protons was measured at 1.5 T and room temperature as a function of macromolecular content in model systems. Gd-DTPA relaxivity was found to increase with macromolecular concentration. The results of this study indicate that the Gd-DTPA relaxivity in tissue extracellular compartment could be as much as 30-70% higher than that of Gd-DTPA in saline. Quantitative MR analyses that use T(1) as an estimation of local Gd-DTPA concentration require a priori determination of the Gd relaxivity in tissue.
在1.5T和室温下，测量了模型系统中水质子的钆-二乙三胺五醋酸（Gd-DTPA）纵向弛豫率，作为大分子含量的函数。发现Gd-DTPA弛豫率随大分子浓度增加而升高。本研究结果表明，组织细胞外间隙中的Gd-DTPA弛豫率可能比盐水中的Gd-DTPA弛豫率高30%-70%。使用纵向弛豫时间（T(1)）估计局部Gd-DTPA浓度的定量磁共振分析需要事先确定组织中的钆弛豫率。
