多发性硬化症免疫遗传学。与人类白细胞HL - A抗原的可能关联。
Multiple sclerosis immunogenetics. A possible correlation with human leukocyte HL-A antigens.
作者信息
Cazzullo C L, Smeraldi E
出版信息
Arzneimittelforschung. 1975 Nov;25(11):1826-8.
To investigate the relationships of genotype to susceptibility to multiple sclerosis, 42 patients hospitalized into Multiple Sclerosis Study Center of The Milan Medical School were typed for 14 HL-A specificities: HL-A1, HL-A2 + W 28, HL-A3, HL-A10 + W 19, HL-A11, HL-A9 of the 1st Series and HL-A5, HL-A7, HL-A8, HL-A12, HL-A13 of the 2nd Series. The increased HL-A9 frequency found in a previous study has been confirmed. Moreover in the total of multiple sclerosis patients this deviation reaches a higher degree of significance (P less than 0.01) and one antigen HL-A10 + W 19 appears to be significantly decreased (P less than 0.01). No variations were found in HL-A3, HL-A7 frequencies.
为了研究基因型与多发性硬化易感性之间的关系，对米兰医学院多发性硬化研究中心收治的42例患者进行了14种HL-A特异性分型：第一组的HL-A1、HL-A2 + W 28、HL-A3、HL-A10 + W 19、HL-A11、HL-A9，以及第二组的HL-A5、HL-A7、HL-A8、HL-A12、HL-A13。先前研究中发现的HL-A9频率增加得到了证实。此外，在所有多发性硬化患者中，这种偏差达到了更高的显著性水平（P小于0.01），并且一种抗原HL-A10 + W 19似乎显著降低（P小于0.01）。HL-A3、HL-A7频率未发现变化。
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