McNeil I A, Culbert B, Russell I
Department of Anaesthesia, Hull Royal Infirmary, UK.
Br J Anaesth. 2000 Oct;85(4):623-5. doi: 10.1093/bja/85.4.623.
We evaluated the intubating conditions, haemodynamic responses and duration of apnoea in 60 healthy adult patients after propofol 2 mg kg-1 combined with either a bolus of remifentanil 2 micrograms kg-1 or 4 micrograms kg-1, or succinylcholine 1 mg kg-1. Patients intubated following remifentanil showed dose-dependent intubating conditions, similar at 4 micrograms kg-1 to the conditions produced with succinylcholine. Post-induction mean arterial pressure decreased from baseline values by 21% (P < 0.0001), 28% (P < 0.0001) and 8% (P > 0.05) in the remifentanil 2 micrograms kg-1, remifentanil 4 micrograms kg-1 and succinylcholine 1 mg kg-1 groups, respectively. The mean (SD) duration of apnoea following induction was 9.3 (2.6) min and 12.8 (2.9) min in the remifentanil 2 micrograms kg-1 and 4 micrograms kg-1 groups, and 6.0 (0.9) min in the succinylcholine group (P < 0.001 between groups).
我们评估了60例健康成年患者在给予2mg/kg丙泊酚后，联合给予2μg/kg或4μg/kg瑞芬太尼推注，或1mg/kg琥珀酰胆碱后的插管条件、血流动力学反应及呼吸暂停持续时间。接受瑞芬太尼插管的患者表现出剂量依赖性的插管条件，4μg/kg时与琥珀酰胆碱产生的条件相似。诱导后，瑞芬太尼2μg/kg组、瑞芬太尼4μg/kg组和琥珀酰胆碱1mg/kg组的平均动脉压分别较基线值下降21%（P<0.0001）、28%（P<0.0001）和8%（P>0.05）。诱导后呼吸暂停的平均（标准差）持续时间在瑞芬太尼2μg/kg组和4μg/kg组分别为9.3（2.6）分钟和12.8（2.9）分钟，在琥珀酰胆碱组为6.0（0.9）分钟（组间P<0.001）。
