Dorazi Robert, Dewar Susan J
Department of Biological Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK1.
Microbiology (Reading). 2000 Nov;146 ( Pt 11):2891-2899. doi: 10.1099/00221287-146-11-2891.
The formation of the Escherichia coli division septum has been well characterized and the majority of the genes involved have been shown to map to the dcw cluster. One exception is ftsK, which lies at 20 minutes, immediately downstream of the global response regulatory gene, lrp. The promoter for ftsK has not yet been assigned. Here, it is reported that ftsK is transcribed from two promoters; the first is located within the lrp reading frame and is dispensable whilst the second is essential and corresponds to dinH, previously characterized as an SOS promoter regulated by LexA. ftsK is the first essential gene to be described that is controlled by an SOS-inducible promoter. A possible mechanism by which dinH may be activated in recA minus strains, or in strains with uncleavable LexA, is discussed.
大肠杆菌分裂隔膜的形成已得到充分表征，且大多数相关基因已被证明定位于dcw簇。一个例外是ftsK，它位于20分钟处，紧邻全局响应调节基因lrp的下游。ftsK的启动子尚未确定。在此，据报道ftsK由两个启动子转录；第一个位于lrp阅读框内，是可有可无的，而第二个是必需的，对应于dinH，dinH先前被表征为受LexA调控的SOS启动子。ftsK是第一个被描述为由SOS诱导型启动子控制的必需基因。本文还讨论了dinH在recA缺陷型菌株或LexA不可裂解的菌株中可能被激活的一种机制。
