Koike M, Yasui K, Torii A, Kodama S
Department of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Japan.
Ann Surg. 2000 Nov;232(5):653-7. doi: 10.1097/00000658-200011000-00006.
To correlate the microscopic finding of entrapped liver cells in hepatic metastases from colorectal cancer with outcome after hepatectomy.
Reliable histopathologic prognostic factors in resected liver metastases from colorectal cancer have not been identified.
Seventy-one patients undergoing radical hepatectomy for liver metastases were assigned to rare (n = 36) or frequent (n = 35) groups according to the microscopically observed frequency of hepatocyte entrapment in the tumor.
Five-year survival rates after hepatectomy were 44. 4% for the rare group and 27.2% for the frequent group. Multivariate analysis using the Cox proportional hazards model by a stepwise method identified this morphologic variable as a significant independent prognostic factor.
The finding of entrapped liver cells in metastases from colorectal cancer reflects the biologic activity of the tumor and may be a useful prognostic indicator.
将结直肠癌肝转移灶中肝实质细胞包绕的显微镜下表现与肝切除术后的预后相关联。
尚未确定切除的结直肠癌肝转移灶中可靠的组织病理学预后因素。
71例行肝转移灶根治性肝切除术的患者,根据显微镜下观察到的肿瘤中肝细胞包绕频率分为少见组(n = 36)和常见组(n = 35)。
少见组肝切除术后5年生存率为44.4%,常见组为27.2%。采用逐步法的Cox比例风险模型进行多因素分析,确定该形态学变量为显著的独立预后因素。
结直肠癌转移灶中肝实质细胞包绕的表现反映了肿瘤的生物学活性,可能是一个有用的预后指标。