Yasui K, Hirai T, Kato T, Torii A, Uesaka K, Morimoto T, Kodera Y, Yamamura Y, Kito T, Hamajima N
Department of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Japan.
Ann Surg. 1997 Nov;226(5):582-6. doi: 10.1097/00000658-199711000-00002.
The authors defined a new macroscopic classification of liver metastases from colorectal cancer.
There were different prognostic results after the same operative procedure for liver metastases with similar background factors.
Eighty-one resected liver metastases were classified into simple nodular (SN) or confluent nodular (CN) types according to the characteristics of the cut surface of the tumor.
The 5-year survival rates after hepatectomy were 41.7% for the SN lesions (n = 39) and 23.1% for the CN lesions (n = 42). The difference between the survival curves was statistically significant (p = 0.0307). Multivariate analysis using Cox's proportional hazards model revealed that the macroscopic type (p = 0.023), the tumor diameter (p = 0.0001), and the presence of lymph node metastases (p = 0.0016) were statistically significant independent prognostic factors.
The new macroscopic classification may be valuable as a prognostic factor reflecting the biologic behavior of liver metastases.
作者定义了一种新的结直肠癌肝转移宏观分类。
对于具有相似背景因素的肝转移，相同手术操作后的预后结果不同。
根据肿瘤切面特征，将81例切除的肝转移灶分为单纯结节型（SN）或融合结节型（CN）。
肝切除术后，SN病变（n = 39）的5年生存率为41.7%，CN病变（n = 42）的5年生存率为23.1%。生存曲线之间的差异具有统计学意义（p = 0.0307）。使用Cox比例风险模型进行的多变量分析显示，宏观类型（p = 0.023）、肿瘤直径（p = 0.0001）和淋巴结转移的存在（p = 0.0016）是具有统计学意义的独立预后因素。
新的宏观分类作为反映肝转移生物学行为的预后因素可能具有价值。
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