Sprich S, Biederman J, Crawford M H, Mundy E, Faraone S V
Cognitive-Behavioral Therapy Program of the Psychiatry Service, Massachusetts General Hospital, Boston 02114, USA.
J Am Acad Child Adolesc Psychiatry. 2000 Nov;39(11):1432-7. doi: 10.1097/00004583-200011000-00018.
Using an adoption study design, the authors addressed the issue of genetics in attention-deficit hyperactivity disorder (ADHD).
This study examined the rates of ADHD and associated disorders in the first-degree adoptive relatives of 25 adopted probands with ADHD and compared them with those of the first-degree biological relatives of 101 nonadopted probands with ADHD and 50 nonadopted, non-ADHD control probands.
Six percent of the adoptive parents of adopted ADHD probands had ADHD compared with 18% of the biological parents of nonadopted ADHD probands and 3% of the biological parents of the control probands.
Results of this study lend support to the hypothesis that ADHD has a genetic component.
作者采用收养研究设计，探讨注意力缺陷多动障碍（ADHD）中的遗传学问题。
本研究调查了25名患有ADHD的被收养先证者的一级收养亲属中ADHD及相关障碍的发生率，并将其与101名未被收养的ADHD先证者和50名未被收养的非ADHD对照先证者的一级生物学亲属的发生率进行比较。
患有ADHD的被收养先证者的收养父母中有6%患有ADHD，相比之下，未被收养的ADHD先证者的生物学父母中有18%患有ADHD，对照先证者的生物学父母中有3%患有ADHD。
本研究结果支持ADHD具有遗传成分这一假说。
