Coyne J C, Benazon N R, Gaba C G, Calzone K, Weber B L
Department of Psychiatry, University of Pennsylvania Health Care System, Philadelphia 19104, USA.
J Consult Clin Psychol. 2000 Oct;68(5):864-74.
This study assessed psychological distress and psychiatric disorder in high-risk women enrolled in a hereditary breast and ovarian cancer registry, and it evaluated the concordance between self-report data and interview-based psychiatric diagnosis. A sample of 464 women completed the Hopkins Symptom Checklist-25 and were interviewed using modules of the Structured Clinical Interview for DSM-IV. Level of psychological distress and the prevalence of psychiatric disorder were low and in the range that would be expected for a sample of community-residing women. Screening proved inefficient: Less than 10% of distressed women met criteria for a clinical disorder. High-risk women seeking genetic testing in research settings may not require extensive psychological screening and diagnostic assessment. Caution is expressed about possible self-selection biases in women enrolled in hereditary cancer registries.
本研究评估了遗传性乳腺癌和卵巢癌登记处登记的高危女性的心理困扰和精神障碍，并评估了自我报告数据与基于访谈的精神科诊断之间的一致性。464名女性完成了霍普金斯症状清单-25，并使用《精神疾病诊断与统计手册》第四版（DSM-IV）结构化临床访谈模块进行了访谈。心理困扰水平和精神障碍患病率较低，处于社区居住女性样本预期的范围内。筛查证明效率低下：不到10%的困扰女性符合临床疾病标准。在研究环境中寻求基因检测的高危女性可能不需要广泛的心理筛查和诊断评估。对遗传性癌症登记处登记的女性可能存在的自我选择偏差表示谨慎。
