Horner P J, Gage F H
The Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA.
Nature. 2000 Oct 26;407(6807):963-70. doi: 10.1038/35039559.
It is self-evident that the adult mammalian brain and spinal cord do not regenerate after injury, but recent discoveries have forced a reconsideration of this accepted principle. Advances in our understanding of how the brain develops have provided a rough blueprint for how we may bring about regeneration in the damaged brain. Studies in developmental neurobiology, intracellular signalling and neuroimmunology are bringing the regeneration field closer to success. Notwithstanding these advances, clear and indisputable evidence for adult functional regeneration remains to be shown.
不言而喻，成年哺乳动物的大脑和脊髓在受伤后不会再生，但最近的发现迫使人们重新审视这一公认的原则。我们对大脑发育过程的理解取得的进展，为我们如何在受损大脑中实现再生提供了一个大致的蓝图。发育神经生物学、细胞内信号传导和神经免疫学方面的研究正使再生领域更接近成功。尽管有这些进展，但成体功能再生的确凿证据仍有待证实。
