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探索生物活性肽对人类神经紊乱的药理作用:综述

Exploring the Pharmacological Effects of Bioactive Peptides on Human Nervous Disorders: A Comprehensive Review.

作者信息

Singh Kuldeep, Gupta Jeetendra Kumar, Shrivastava Aman, Jain Divya, Yadav Amrendra Pratap, Dwivedi Sumeet, Dubey Anubhav, Kumar Shivendra

机构信息

Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.

Department of Pharmacology, Institute of Professional Studies, College of Pharmacy, Gwalior, M.P. India.

出版信息

CNS Neurol Disord Drug Targets. 2025;24(1):32-46. doi: 10.2174/0118715273316382240807120241.

Abstract

A family of peptides known as bioactive peptides has unique physiological properties and may be used to improve human health and prevent illness. Because bioactive peptides impact the immunological, endocrine, neurological, and cardiovascular systems, they have drawn a lot of interest from researchers. According to recent studies, bioactive peptides have a lot to offer in the treatment of inflammation, neuronal regeneration, localized ischemia, and the blood-brain barrier. It investigates various peptide moieties, including antioxidative properties, immune response modulation, and increased blood-brain barrier permeability. It also looks at how well they work as therapeutic candidates and finds promising peptide-based strategies for better outcomes. Furthermore, it underscores the need for further studies to support their clinical utility and suggests that results from such investigations will enhance our understanding of the pathophysiology of these conditions. In order to understand recent advances in BPs and to plan future research, academic researchers and industrial partners will find this review article to be a helpful resource.

摘要

一类被称为生物活性肽的肽具有独特的生理特性,可用于改善人类健康和预防疾病。由于生物活性肽会影响免疫、内分泌、神经和心血管系统,因此引起了研究人员的广泛关注。根据最近的研究,生物活性肽在治疗炎症、神经元再生、局部缺血和血脑屏障方面有很大的作用。它研究了各种肽部分,包括抗氧化特性、免疫反应调节和血脑屏障通透性增加。它还研究了它们作为治疗候选物的效果,并找到了有前景的基于肽的策略以获得更好的结果。此外,它强调了进一步研究以支持其临床应用的必要性,并表明此类研究的结果将增强我们对这些病症病理生理学的理解。为了了解生物活性肽的最新进展并规划未来的研究,学术研究人员和行业合作伙伴会发现这篇综述文章是一个有用的资源。

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