Oon C J, Hobbs J R
Clin Exp Immunol. 1975 Apr;20(1):1-16.
The NCl/IBM or Aminco Continuous Flow Blood Separator Machine is a safe apparatus for the selective removal or exchange of either packed red blood cells, leucocyte-rich or platelet-rich layers or plasma. Abnormal fractions from any of these layers may be collected and discarded. Normal constituents may be collected for therapeutic uses. The wide scope of its applications includes important uses in clinical immunology: temporary provision of good leucocytes or platelets; harvesting of immune leucocytes (preparation of transfer factor at up to 10 units per harvest); removal of cryo- or macro-globulins, immune complexes or blocking factors; replacement therapy for antibody or complement deficiencies. Examples are given of such uses together with some of the medical problems so far encountered.
NCl/IBM 或 Aminco 连续流动血液分离机是一种安全的设备，可用于选择性去除或置换浓缩红细胞、富含白细胞或富含血小板的层或血浆。这些层中的异常成分可被收集并丢弃。正常成分可被收集用于治疗用途。其广泛的应用范围包括临床免疫学中的重要用途：临时提供优质白细胞或血小板；采集免疫白细胞（每次采集制备多达10单位的转移因子）；去除冷球蛋白或巨球蛋白、免疫复合物或封闭因子；抗体或补体缺乏的替代疗法。文中给出了此类用途的示例以及目前遇到的一些医学问题。
