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Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection.单纯疱疹病毒2型被膜蛋白含有在DNA免疫和感染后可在BALB/c小鼠中检测到的亚显性T细胞表位。
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本文引用的文献

1
Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans.在人类单纯疱疹病毒性基质性角膜炎中，被膜特异性、病毒反应性CD4 T细胞定位于角膜。
J Virol. 2000 Dec;74(23):10930-8. doi: 10.1128/jvi.74.23.10930-10938.2000.
2
Intraocular T cells of patients with herpes simplex virus (HSV)-induced acute retinal necrosis recognize HSV tegument proteins VP11/12 and VP13/14.
J Infect Dis. 2000 Sep;182(3):923-7. doi: 10.1086/315759. Epub 2000 Aug 17.
3
Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection.在患有2型单纯疱疹病毒生殖器感染的女性中，抗原特异性T细胞定位于子宫颈。
J Infect Dis. 2000 Sep;182(3):662-70. doi: 10.1086/315749. Epub 2000 Aug 17.
4
Natural infection with herpes simplex virus type 1 (HSV-1) induces humoral and T cell responses to the HSV-1 glycoprotein H:L complex.
J Gen Virol. 2000 Aug;81(Pt 8):2011-2015. doi: 10.1099/0022-1317-81-8-2011.
5
HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells.HLA-DQ四聚体可识别2型单纯疱疹病毒感染个体外周血中表位特异性T细胞：免疫显性抗原反应性细胞的直接检测
J Immunol. 2000 Apr 15;164(8):4244-9. doi: 10.4049/jimmunol.164.8.4244.
6
Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons.无症状血清阳性者中2型单纯疱疹病毒生殖器感染的再激活。
N Engl J Med. 2000 Mar 23;342(12):844-50. doi: 10.1056/NEJM200003233421203.
7
Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice.颗粒酶A是CD8(+)细胞颗粒的一种非溶细胞成分，可限制单纯疱疹病毒在实验感染小鼠外周神经系统中的传播。
J Virol. 2000 Jan;74(2):1029-32. doi: 10.1128/jvi.74.2.1029-1032.2000.
8
Vaccination with different HSV-1 glycoproteins induces different patterns of ocular cytokine responses following HSV-1 challenge of vaccinated mice.用不同的单纯疱疹病毒1型糖蛋白进行疫苗接种后，对接种疫苗的小鼠进行单纯疱疹病毒1型攻击，会诱导出不同模式的眼部细胞因子反应。
Vaccine. 1999 Jun 4;17(20-21):2576-82. doi: 10.1016/s0264-410x(99)00056-0.
9
Cell surface expression of H2 antigens on primary sensory neurons in response to acute but not latent herpes simplex virus infection in vivo.体内原发性感觉神经元上H2抗原的细胞表面表达对急性而非潜伏性单纯疱疹病毒感染的反应。
J Virol. 1999 Aug;73(8):6484-9. doi: 10.1128/JVI.73.8.6484-6489.1999.
10
The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses.维持有效的细胞毒性T淋巴细胞反应对CD4辅助的迫切需求。
J Exp Med. 1998 Dec 21;188(12):2199-204. doi: 10.1084/jem.188.12.2199.

CD4 T细胞对单纯疱疹病毒2型主要衣壳蛋白VP5的反应：与对被膜和包膜糖蛋白反应的比较

CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: comparison with responses to tegument and envelope glycoproteins.

作者信息

Koelle D M, Schomogyi M, McClurkan C, Reymond S N, Chen H B

机构信息

Department of Medicine, University of Washington, Seattle, Washington 98105, USA.

出版信息

J Virol. 2000 Dec;74(23):11422-5. doi: 10.1128/jvi.74.23.11422-11425.2000.

DOI:10.1128/jvi.74.23.11422-11425.2000
PMID:11070045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC113250/
Abstract

We used CD4 lymphocyte clones from herpes simplex virus type 2 (HSV-2) lesions or the cervix and molecular libraries of HSV-2 DNA to define HSV-2 major capsid protein VP5 and glycoprotein E (gE) as T-cell antigens. Responses to eight HSV-2 glycoprotein, tegument, nonstructural, or capsid antigens were compared in 19 donors. Recognition of VP5 and tegument VP22 were similar to that of gB2 and gD2, currently under study as vaccines. These prevalence data suggest that HSV capsid and tegument proteins may also be candidate vaccine antigens.

摘要

我们使用来自2型单纯疱疹病毒（HSV-2）损伤部位或子宫颈的CD4淋巴细胞克隆以及HSV-2 DNA分子文库，将HSV-2主要衣壳蛋白VP5和糖蛋白E（gE）定义为T细胞抗原。在19名供体中比较了对8种HSV-2糖蛋白、被膜、非结构或衣壳抗原的反应。对VP5和被膜蛋白VP22的识别与目前作为疫苗正在研究的gB2和gD2相似。这些流行率数据表明，HSV衣壳蛋白和被膜蛋白也可能是候选疫苗抗原。